Age
|
Muraki [25] 2012
|
Per 5 years increase
|
Incident knee pain at follow-up (baseline K/L ≥2)
|
OR 1.01 (0.95–1.07)
|
o
|
(N = 10,043)
|
Holla [20] 2010
|
Continuous (years)
|
Progressing/remaining in poor WOMAC-PF quintiles
|
OR 0.97 (0.94–1.00)
|
–
|
|
Holla [21] 2014
|
Continuous (years)
|
Poor vs good outcome WOMAC-PF trajectory
|
OR 0.94 (0.88–1.00)
|
–
|
|
Collins [15] 2014
|
Continuous (years)
|
Severe vs no pain WOMAC pain trajectory
|
OR 0.92 (0.89–0.96)
|
–
|
|
Riddle [29] 2009
|
Continuous (years)
|
Knee joint surgery
|
OR 1.07 (1.02–1.11)
|
+
|
|
Riddle [30] 2012
|
Continuous (years)
|
Knee joint surgery
|
RR 1.04 (1.01–1.23)
|
+
|
Female sex
|
Collins [15] 2014
|
Female vs male
|
Severe vs no pain WOMAC pain trajectory
|
OR 3.0 (1.5–6.2)
|
+
|
(N = 3,066)
|
Muraki [25] 2012
|
Female vs male
|
Incident knee pain at follow-up (baseline K/L ≥2)
|
OR 1.32 (0.94–1.84)
|
o
|
Ethnicity
|
Collins [15] 2014
|
Non-white vs white
|
Severe vs no pain WOMAC pain trajectory
|
OR 3.3 (1.7–6.6)
|
+
|
(N = 2,585)
|
Holla [20] 2010
|
Non-western vs western
|
Progressing/remaining in poor WOMAC-PF quintiles
|
OR 4.03 (1.06–15.4)
|
+
|
Education level
|
Collins [15] 2014
|
<College ≥ college
|
Severe vs no pain WOMAC pain trajectory
|
OR 5.1 (2.3–11.2)
|
+
|
(N = 2,531)
|
Riddle [29] 2009
|
≤ High school graduate
|
Knee joint surgery
|
OR 2.40 (1.09–5.28)
|
+
|
Body mass index (N = 4,857)
|
Holla [20] 2010
|
Continuous
|
Progressing/remaining in poor WOMAC-PF quintiles
|
OR 1.06 (1.02–1.11)
|
+
|
Sharma [34] 2003
|
Per 5 unit increase
|
Progressing/remaining in poor WOMAC-PF quintiles
|
OR 1.15 (0.89–1.46)
|
o
|
Collins [15] 2014
|
Obese vs non-obese
|
Severe vs no pain WOMAC pain trajectory
|
OR 2.3 (1.2–4.4)
|
+
|
Holla [21] 2014
|
Continuous
|
Moderate vs good outcome WOMAC-PF trajectory
|
OR 1.12 (1.07–1.18)
|
+
|
Muraki [25] 2012
|
Per 5 units increase
|
Incident knee pain at follow-up (baseline K/L ≥2)
|
OR 1.54 (1.90–1.82)
|
+
|
Riddle [29] 2009
|
≤30 vs >30 kg/m2
|
Knee joint surgery
|
OR 2.66 (1.20–5.92)
|
+
|
Bodyweight change
|
Riddle [31] 2013
|
≥–10 % vs –4.9 to +4.9 %
| |
β 4.07 (1.49–6.65)
|
–
|
(N = 1,410)
| |
–9.9 to –5 % vs –4.9 to +4.9 %
|
Increase self-reported limitations (WOMAC-PF)
|
β 0.01 (–1.87 to 1.89)
|
o
|
| |
+5 to +9.9 % vs –4.9 to +4.9 %
|
Increase in pain (WOMAC); similar results, not tabulated
|
β 1.08 (–0.91 to 3.07)
|
o
|
| |
≥ + 10 % vs –4.9 to +4.9 %
| |
β –5.36 (–8.74 to –2.00)
|
+
|
Knee compression force
|
Henriksen [18] 2013
|
Change in peak knee joint compressive force
|
Change in KOOS-4
|
LSMD –2.4 (–6.8 to 1.9)
|
o
|
(N = 157)
| |
Change in walking speed, m/s
|
LSMD –0.01 (–0.05 to 0.03)
|
o
|
Co-morbidity count
|
Holla [20] 2010
|
≥3 vs none
|
Progressing/remaining in poor WOMAC-PF quintiles
|
OR 1.53 (0.93–2.53)
|
o
|
(N = 3,672)
|
Holla [21] 2014
|
≥3 vs < 3
|
Poor vs good outcome WOMAC-PF trajectory
|
OR 3.28 (1.62–6.64)
|
+
|
|
Collins [15] 2014
|
≥1 vs 0
|
Severe vs no pain WOMAC pain trajectory
|
OR 2.0 (1.0–3.9)
|
+
|
|
Pisters [27] 2012
|
Per unit CIRS increase
|
Increase in self-reported limitations (WOMAC-PF)
|
β 3.69 (1.66–8.23)
|
+
|
|
Van Dijk [37] 2011
|
Per unit CIRS increase
|
Increase in self-reported limitations (WOMAC-PF)
|
β –0.147 (not provided)
|
+
|
| | |
Increase in performance-based limitations (TWT)
|
β 0.150 (not provided)
|
+
|
Mental health
|
Collins [15] 2014
|
CES-D ≥16 vs CES-D < 16
|
Severe vs no pain WOMAC pain trajectory
|
OR 8.8 (3.1–25.2)
|
+
|
(N = 6,659)
|
Sharma [34] 2003
|
Per 5 points score
|
Progressing/remaining in poor WOMAC-PF quintiles
|
OR 0.58 (0.39–0.86)
|
–
|
|
Riddle [30] 2012
|
Per unit SF-12 MCS score
|
Knee joint surgery
|
RR 1.07 (1.04–1.10)
|
+
|
Vitality
|
Holla [21] 2014
|
Per unit SF-36 HS score
|
Poor vs good outcome WOMAC-PF trajectory
|
OR 0.96 (0.94–0.98)
|
–
|
(N = 871)
|
Van Dijk [37] 2011
|
Per unit SF-36 MOS score
|
Increase in self-reported limitations (WOMAC-PF)
|
β 0.157 (not provided)
|
–
|
| | |
Increase in performance-based limitations (TWT)
|
β –0.229 (not provided)
|
–
|
Pain coping
|
Alschuler [9] 2013
|
CSQ subscale praying or hoping
|
≥20 % change in combined NRS and WOMAC-PF score
|
Not provided
|
+
|
(N = 1,048)
| |
CSQ subscale catastrophizing
|
≥20 % change in combined NRS or WOMAC-PF score
|
Not provided
|
+
|
Holla [20] 2010
|
PCI subscale distraction
|
Progressing/remaining in poor WOMAC-PF quintiles
|
OR 1.26 (0.98–1.62)
|
o
|
|
PCI subscale worrying
|
OR 0.63 (0.66–0.73)
|
–
|
Holla [21] 2014
|
PCI subscale resting
|
Poor vs good outcome WOMAC-PF trajectory
|
OR 1.16 (1.02–1.31)
|
+
|
Pisters [27] 2012
|
PCI subscale resting
|
Increase in self-reported limitations (WOMAC-PF)
|
β 23.3 (1.93–280.7)
|
+
|
| | |
Increase in performance-based limitations (TWT)
|
β 3.13 (1.95–5.03)
|
+
|
Morning stiffness
|
Holla [20] 2010
|
<30 minutes, yes vs no
|
Progressing/remaining in poor WOMAC-PF quintiles
|
OR 1.37 (0.99–1.88)
|
o
|
(N = 832)
| | | | | |
Knee injury
|
Muraki [25] 2012
|
Previous knee injury
|
Incident knee pain at follow-up (baseline K/L ≥2)
|
OR 2.91 (1.26–6.82)
|
+
|
(N = 1,313)
| | | | | |
Knee surgery
|
Riddle [30] 2012
|
History of knee surgery
|
Knee joint surgery
|
RR 2.04 (1.33–3.13)
|
+
|
(N = 4,670)
| | | | | |
Pain medication use
|
Riddle [30] 2012
|
For pain, aching or stiffness
|
Knee joint surgery
|
RR 1.64 (0.87–3.12)
|
o
|
(N = 6,516)
|
Lapane [22] 2015
|
NSAID usage vs not
|
MICD of WOMAC pain
|
β –0.88 (–2.22 to 0.46)
|
o
|
| | |
MICD of WOMAC-PF
|
β –4.27 (–8.84 to 0.31)
|
o
|
| | |
MICD of WOMAC stiffness
|
β –0.72 (–1.56 to 0.12)
|
o
|
Bisphosphonate use
|
Laslett [24] 2014
|
Yes vs no
|
Decrease in WOMAC pain
|
β 0.69 (–0.54 to 1.92)
|
o
|
(N = 323)
| | |
Decrease in WOMAC function
|
β 0.05 (–3.85 to 3.95)
|
o
|
| | |
Decrease in WOMAC stiffness
|
β –0.24 (–0.75 to 0.27)
|
o
|
| | |
Decrease in NRS after 3 and 4 years, but not 5 years
|
β –1.15 (–1.94 to –0.36)
|
+
|
Glucosamine/chondroitin use
|
Yang [38] 2015
|
Yes vs no
|
MICD of WOMAC pain
|
β 0.68 (–0.16 to 1.53)
|
o
|
| |
MICD of WOMAC-PF
|
β 1.28 (–1.23 to 3.79)
|
o
|
(N = 1,625)
| | |
MICD of WOMAC stiffness
|
β 0.41 (0–0.82)
|
o
|
History of HRS
|
Riddle [30] 2012
|
Yes vs no
|
Knee joint surgery
|
RR 2.73 (0.93–8.07)
|
o
|
(N = 4,670)
| | | | | |