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Table 3 Comparison of screening algorithms for pulmonary hypertension in systemic sclerosis

From: Stress Doppler echocardiography for early detection of systemic sclerosis-associated pulmonary arterial hypertension

Approach False negatives, % (missed diagnoses) Sensitivity, % Specificity, % PPV, % NPV, %
SDE at rest and during exercise 1 96 82 68 98
N = 76      
DETECT algorithm 4 96 48 35 98
N = 319      
DETECT algorithm with 15 85 72 47 94
65 % specificity at step 2      
N = 319      
DETECT data with algorithm from      
ESC/ERS guidelines* 29 71 69 40 89
N = 371      
  1. PPV positive predictive value (confirmed pulmonary arterial hypertension out of all right heart catheterization referrals), NPV negative predictive value, SDE stress Doppler echocardiography, ESC/ERS European Society of Cardiology/European Respiratory Society
  2. Adaptation of the table provided by Coghlan et al. [11] in the DETECT study
  3. *Evaluated on a subset of patients from DETECT study (n = 371) with available data for the variables defined in the guideline
  4. Criteria were the following: (a) tricuspid regurgitant jet velocity >3.4 m/s or (b) tricuspid regurgitant jet velocity >2.8 to ≤ 3.4 m/s AND symptomatic (defined as at least one of the following DETECT parameters: current anginal pain, current syncope/near syncope, current dyspnoea, or presence of peripheral oedema) or (c) tricuspid regurgitant jet velocity ≤2.8 m/s AND symptomatic (defined as above) AND presence of additional echocardiography variables suggestive of pulmonary hypertension (defined as right atrium area >16 cm2 or ratio of right ventricular diameter/left ventricular end diastolic diameter >0.8 or both)