|
Approach
|
False negatives, % (missed diagnoses)
|
Sensitivity, %
|
Specificity, %
|
PPV, %
|
NPV, %
|
|---|
|
SDE at rest and during exercise
|
1
|
96
|
82
|
68
|
98
|
|
N = 76
| | | | | |
|
DETECT algorithm
|
4
|
96
|
48
|
35
|
98
|
|
N = 319
| | | | | |
|
DETECT algorithm with
|
15
|
85
|
72
|
47
|
94
|
|
65 % specificity at step 2
| | | | | |
|
N = 319
| | | | | |
|
DETECT data with algorithm from
| | | | | |
|
ESC/ERS guidelines*
|
29
|
71
|
69
|
40
|
89
|
|
N = 371
| | | | | |
-
PPV positive predictive value (confirmed pulmonary arterial hypertension out of all right heart catheterization referrals), NPV negative predictive value, SDE stress Doppler echocardiography, ESC/ERS European Society of Cardiology/European Respiratory Society
- Adaptation of the table provided by Coghlan et al. [11] in the DETECT study
- *Evaluated on a subset of patients from DETECT study (n = 371) with available data for the variables defined in the guideline
- Criteria were the following: (a) tricuspid regurgitant jet velocity >3.4 m/s or (b) tricuspid regurgitant jet velocity >2.8 to ≤ 3.4 m/s AND symptomatic (defined as at least one of the following DETECT parameters: current anginal pain, current syncope/near syncope, current dyspnoea, or presence of peripheral oedema) or (c) tricuspid regurgitant jet velocity ≤2.8 m/s AND symptomatic (defined as above) AND presence of additional echocardiography variables suggestive of pulmonary hypertension (defined as right atrium area >16 cm2 or ratio of right ventricular diameter/left ventricular end diastolic diameter >0.8 or both)
