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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy: implications for joint remodeling in AS

Fig. 2

No evidence for stage-dependent induction of chondrocyte hypertrophy. Representative immunohistochemical staining of safranin-O/light green (a) from facet joints of patients with ankylosing spondylitis with open joints (AS stage I), with cartilaginous fused joints (AS stage II) and with bony fused joints (AS stage III). Representative immunohistochemical staining and percentage of chondrocytes that were positive for Runx2 (b), MMP13 (c) and COL10 (d) within the hyaline articular cartilage of facet joints from patients with AS stage I (B–D first column), AS stage II (B–D second column) and AS stage III (B–D third column); original magnification 40× and 400×; dashed line indicates the median of the control group. COL10 type X collagen, MMP matrix metalloproteinase, Runx2, runt-related transcription factor 2

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