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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis

Fig. 4

Quantitative PCR analysis of inflammatory and anti-inflammatory mediators in synovial tissue after adenoviral transfer into the knee joint. a Interleukin (IL)-17, granulocyte macrophage colony-stimulating factor (GM-CSF), RAR-related orphan receptor γt (RORγt) and IL-23 expression in synovial tissue determined at 4 h, day 1 and day 4 after adenoviral transfer. b Proinflammatory mediators IL-1β, receptor activator of nuclear factor κB ligand (RANKL) and S100A8 expression in synovial tissue determined at 4 h, day 1 and day 4 after adenoviral transfer. c Matrix metalloproteinase (MMP) expression in synovial tissue determined at 4 h, day 1 and day 4 after adenoviral transfer. d Expression of MMP inhibitors in synovial tissue determined at 4 h, day 1 and day 4 after adenoviral transfer. n = 6 joints/group. Mean ± standard error of the mean. *p < 0.05, **p < 0.01 vs. Ad-IL-17; § p < 0.05, p < 0.001, # p < 0.0001 vs. Ad-IL-17 + Ad-GM-CSF; analysis of variance followed by Bonferroni’s test for multiple comparisons. ADAMTS5 a disintegrin and metalloproteinase with thrombospondin motifs, TF transcription factor, TIMP tissue inhibitor of matrix metalloproteinase

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Arthritis Research & Therapy

ISSN: 1478-6362

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