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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Reactivity of rat bone marrow-derived macrophages to neurotransmitter stimulation in the context of collagen II-induced arthritis

Fig. 1

Number of BMMs and analysis of surface marker expression by flow cytometry. a Total number of BMMs from control and arthritic rats was determined after 2 days of pre-culture with M-CSF. **P < 0.01. N (control/CIA) = day 10 (9/10), day 15 (10/9), day 20 (10/9), and day 40 (10/9). b Native bone marrow cells of control and arthritic rats harvested at the acute disease state (20 days) were characterized by flow cytometry for macrophage-associated markers CD11b and EMR1. *P < 0.05, **P < 0.01. N = 6 for control and CIA. c BMMs of control and arthritic animals were harvested after 2 days of pre-culture with M-CSF and characterized by flow cytometry for macrophage-associated surface marker expression of CD11b and EMR1. CD11b: N = 7, EMR1: N = 8 for control and CIA BMMs (sum-up of experimental time points, each N comprises pooled BMMs from 1–3 animals that were either control or CIA). Boxplots show box with median and interquartile range and whiskers from minimum to maximum. BMM bone marrow-derived macrophage, CD11b cluster of differentiation 11b, CIA collagen II-induced arthritis, EMR1 epidermal growth factor-like module-containing mucine-like hormone receptor-like 1, M-CSF macrophage colony-stimulating factor

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