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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Epratuzumab inhibits the production of the proinflammatory cytokines IL-6 and TNF-α, but not the regulatory cytokine IL-10, by B cells from healthy donors and SLE patients

Fig. 2

Epratuzumab does not influence the generation of intracellular interleukin (IL)-10-positive B cells. (a) Frequency of intracellular IL-10+ B cells after 2 days of peripheral blood mononuclear cell culture of representative healthy donors (HD) or patients with systemic lupus erythematosus, respectively, without stimulation (RPMI 1640 medium) or stimulated by anti–B cell receptor (anti-BCR) or anti-BCR + CpG using flow cytometry. (b) Comparison of the frequency of IL-10–producing B cells from 6 patients with SLE and 10 HD without (open squares) and with F(ab′)2 epratuzumab (gray squares) incubation in response to the indicated stimulations (Mann–Whitney U test)

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