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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Epratuzumab inhibits the production of the proinflammatory cytokines IL-6 and TNF-α, but not the regulatory cytokine IL-10, by B cells from healthy donors and SLE patients

Fig. 3

Epratuzumab influences the balance between interleukin (IL)-10 and the proinflammatory cytokines tumor necrosis factor (TNF)-α and IL-6 secreted by B cells activated by anti–B cell receptor (anti-BCR) + CpG in patients with systemic lupus erythematosus (SLE). The balance between IL-10 and proinflammatory cytokines (IL-6 and TNF-α) produced by B cells from healthy donors (HD) and patients with SLE was evaluated based on the ratio of IL-10 to IL-6 (a) or IL-10 to TNF-α (b) (Mann–Whitney U test; **p < 0.01)

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