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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Suppressed diversity of survivin splicing in active rheumatoid arthritis

Fig. 2

Levels of survivin splice variants in peripheral blood mononuclear cells (PBMCs) and bone marrow (BM) of patients with rheumatoid arthritis. a mRNA levels of survivin-WT, survivin-2B and survivin-ΔEx3 were measured in 67 PBMC samples and 23 BM samples and expressed as the relative quantity (RQ) of the reference group PBMC within each splice variant. b Combination of the splice variants in 67 PBMC samples. c Total mRNA level of survivin splice variants in PBMC samples, expressed as the RQ of survivin-WT in the group containing all splice variants. d Serum levels of survivin within the allocated groups. Boxes represent the 25th–75th percentile of the group; horizontal lines indicate median values and error bars show the range. e Disease Activity Score (DAS28) within the allocated groups. Boxes represent the 25th–75th percentile of the group; horizontal lines indicate median values and error bars show the range. f Survivin-2B/WT ratio and g survivin-ΔEx3/WT ratio in PBMCs for patients in remission (DAS <3.2), in active RA (DAS28 3.2–5.1) and in high active RA (DAS28 >5.1). Lines indicate mean values within each group. h Survivin-2B/WT ratio in PBMCs of patients with different treatment modalities. Horizontal lines indicate median value for the group. DMARD disease-modifying anti-rheumatic drug, MTX methotrexate, +anti-TNF combination of MTX and tumour necrosis factor inhibitors, +RTX combination of MTX and rituximab, RA rheumatoid arthritis, WT wild type

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