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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Differences in glutamate receptors and inflammatory cell numbers are associated with the resolution of pain in human rotator cuff tendinopathy

Fig. 5

Neuro-inflammatory genes are upregulated in cells derived from rotator cuff tendon tears versus control cells. The expression of the TNF-α (9.5-fold, p = 0.0009), CD45 (12.3-fold, p = 0.03), CD206 (2-fold, p = 0.004), NMDAR1 (3.5-fold, p = 0.003), KA1 (7.5-fold, p = 0.049) and mGluR2 (205-fold, p = 0.0006) genes was significantly increased in tendon tear-derived cells (a) proliferation, cell surface markers and matrix genes (b) cytokine and glutaminergic genes (n = 7 tendon tear-derived and 5 controls). The boxes represent median +/− interquartile range, while the whiskers represent range. Numbers in outlined boxes represent fold change in gene expression. Statistical significance denoted by * p <0.05, ** p <0.01, *** p <0.001. KA1 kainate receptor 1, mGluR metabotropic glutamate receptor, NMDAR N-methyl-D-aspartate receptor, TNF-α tumour necrosis factor alpha

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