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Table 2 Data representing the basic histological characteristics and quantified immunohistochemistry

From: Differences in glutamate receptors and inflammatory cell numbers are associated with the resolution of pain in human rotator cuff tendinopathy

  Pain-free group Painful group p value
Mean vessel count 1.09 (+/− 0.63) 0.80 (+/− 0.65) 0.47
Mean nuclei count 11.6 (+/− 4.1) 8.0 (+/− 12.5) 0.57
Median modified Bonar score 7.0 (6.5–8.0) 8.0 (6.0–10.0) 0.59
Proliferation (% PCNA staininga) 0.04 (0.03–0.06) 0.04 (0.02–0.12) 0.86
HIF1alphaa 0.01 (0.01–0.04) 0.02 (0.01–0.04) 0.73
VEGFa 0.27 (+/− 0.18) 0.06 (+/− 0.05) 0.004**b
CD45 (% cells positive) 6.8 (4.7–10) 12.4 (8.1–16.8) 0.038*
CD206 (% cells positive) 13.2 (+/− 6.2) 26.8 (+/− 6.5) 0.0004**b
Lactate dehydrogenasea 0.001 (0.0004–0.002) 0.015 (0.01–0.04) 0.007**b
Glutamatea 0.003 (0.001–0.03) 0.004 (0.002–0.007) 0.86
NMDAR1a 0.013 (0.006–0.015) 0.025 (0.002–0.037) 0.61
PGP 9.5 0.87 (0.35–1.86) 3.75 (1.36–4.97) 0.0079**b
mGluR1a 0.43 (0.24–0.58) 0.36 (0.24–0.42) 0.55
mGluR2a 0.0019 (0.008–0.066) 0.064 (0.058–0.096) 0.05*
mGluR7a 0.18 (0.12–0.64) 0.005 (0.003–0.034) 0.0019**b
KA1 0.85 (1.31–2.62) 4.55 (2.37–7.15) 0.0028**b
  1. All data is represented as median (interquartile range) or mean +/− standard deviation unless otherwise stated. Statistical significance is denoted by * p <0.05, ** p <0.01, *** p <0.001 (between groups).
  2. HIF1alpha hypoxia-inducible factor 1-alpha, KA1 kainate receptor 1, mGluR metabotropic glutamate receptor, NMDAR1 N-methyl-D-aspartate receptor, PCNA proliferating cell nuclear antigen, PGP 9.5 protein gene product 9.5, VEGF vascular endothelial growth factor
  3. aDenotes per cell
  4. bDenotes significant result after application of Benjamini-Hochberg procedure