Differences in glutamate receptors and inflammatory cell numbers are associated with the resolution of pain in human rotator cuff tendinopathy

Table 2 Data representing the basic histological characteristics and quantified immunohistochemistry

	Pain-free group	Painful group	p value
Mean vessel count	1.09 (+/− 0.63)	0.80 (+/− 0.65)	0.47
Mean nuclei count	11.6 (+/− 4.1)	8.0 (+/− 12.5)	0.57
Median modified Bonar score	7.0 (6.5–8.0)	8.0 (6.0–10.0)	0.59
Proliferation (% PCNA staining^a)	0.04 (0.03–0.06)	0.04 (0.02–0.12)	0.86
HIF1alpha^a	0.01 (0.01–0.04)	0.02 (0.01–0.04)	0.73
VEGF^a	0.27 (+/− 0.18)	0.06 (+/− 0.05)	0.004^**b
CD45 (% cells positive)	6.8 (4.7–10)	12.4 (8.1–16.8)	0.038^*
CD206 (% cells positive)	13.2 (+/− 6.2)	26.8 (+/− 6.5)	0.0004^**b
Lactate dehydrogenase^a	0.001 (0.0004–0.002)	0.015 (0.01–0.04)	0.007^**b
Glutamate^a	0.003 (0.001–0.03)	0.004 (0.002–0.007)	0.86
NMDAR1^a	0.013 (0.006–0.015)	0.025 (0.002–0.037)	0.61
PGP 9.5	0.87 (0.35–1.86)	3.75 (1.36–4.97)	0.0079^**b
mGluR1^a	0.43 (0.24–0.58)	0.36 (0.24–0.42)	0.55
mGluR2^a	0.0019 (0.008–0.066)	0.064 (0.058–0.096)	0.05^*
mGluR7^a	0.18 (0.12–0.64)	0.005 (0.003–0.034)	0.0019^**b
KA1	0.85 (1.31–2.62)	4.55 (2.37–7.15)	0.0028^**b

All data is represented as median (interquartile range) or mean +/− standard deviation unless otherwise stated. Statistical significance is denoted by ^* p <0.05, ^** p <0.01, ^*** p <0.001 (between groups).
HIF1alpha hypoxia-inducible factor 1-alpha, KA1 kainate receptor 1, mGluR metabotropic glutamate receptor, NMDAR1 N-methyl-D-aspartate receptor, PCNA proliferating cell nuclear antigen, PGP 9.5 protein gene product 9.5, VEGF vascular endothelial growth factor
^aDenotes per cell
^bDenotes significant result after application of Benjamini-Hochberg procedure

ISSN: 1478-6362