|
HLA-DRB1 allele
|
Allele frequency in controls, N (%)
|
Allele frequency in cases, N (%)
|
Allele frequency in biopsy-positive cases, N (%)
|
Unadjusted OR (95 % CI)
|
P value
|
OR adjusted for *04 (95 % CI)
|
P value
|
|---|
|
*01
|
341 (12.4)
|
27 (6.0)
|
12 (4.3)
|
0.46 (0.31, 0.69)
|
1.6×10−4
|
0.55 (0.37, 0.83)
|
0.0046
|
|
*03
|
438 (15.9)
|
75 (16.7)
|
41 (14.5)
|
1.06 (0.81, 1.39)
|
0.68
|
1.31 (0.99, 1.74)
|
0.061
|
|
*04
|
503 (18.3)
|
138 (30.7)
|
89 (31.6)
|
2.03 (1.61, 2.56)
|
1.7×10−9
|
-
|
-
|
|
*04:01
|
304 (11.0)
|
83 (18.4)
|
54 (19.1)
|
1.87 (1.42, 2.46)
|
8.2×10−6
|
-
|
-
|
|
*04:02
|
10 (0.4)
|
2 (0.4)
|
1 (0.4)
|
1.29 (0.64, 2.59)*
|
0.48*
|
-
|
-
|
|
*04:03
|
38 (1.4)
|
8 (1.8)
|
7 (2.5)
|
|
*04:04/04:08
|
151 (5.5)
|
45 (10.0)
|
27 (9.6)
|
1.86 (1.32, 2.63)
|
3.7×10−4
|
-
|
-
|
|
*07
|
393 (14.3)
|
57 (12.7)
|
34 (12.1)
|
0.88 (0.65, 1.17)
|
0.37
|
1.03 (0.76, 1.39)
|
0.85
|
|
*08
|
78 (2.8)
|
8 (1.8)
|
4 (1.4)
|
0.62 (0.30, 1.29)
|
0.20
|
0.75 (0.36, 1.57)
|
0.45
|
|
*09
|
30 (1.1)
|
5 (1.1)
|
5 (1.8)
|
1.02 (0.39, 2.66)
|
0.97
|
1.19 (0.45, 3.12)
|
0.73
|
|
*10
|
21 (0.8)
|
0 (0.0)
|
0 (0.0)
|
-
|
-
|
-
| |
|
*11
|
179 (6.5)
|
32 (7.1)
|
20 (7.1)
|
1.09 (0.75, 1.59)
|
0.64
|
1.25 (0.86, 1.83)
|
0.25
|
|
*12
|
49 (1.8)
|
10 (2.2)
|
6 (2.1)
|
1.24 (0.64, 2.42)
|
0.53
|
1.60 (0.81, 3.14)
|
0.18
|
|
*13
|
222 (8.1)
|
41 (9.1)
|
32 (11.3)
|
1.14 (0.81, 1.62)
|
0.45
|
1.35 (0.95, 1.93)
|
0.098
|
|
*14
|
60 (2.2)
|
10 (2.2)
|
5 (1.7)
|
1.02 (0.52, 2.00)
|
0.95
|
1.29 (0.65, 2.56)
|
0.46
|
|
*15
|
421 (15.3)
|
45 (10.0)
|
32 (11.3)
|
0.63 (0.46, 0.87)
|
0.0047
|
0.75 (0.54, 1.04)
|
0.085
|
|
*16
|
21 (0.8)
|
2 (0.4)
|
2 (0.7)
|
0.58 (0.13, 2.49)
|
0.46
|
0.67 (0.16, 2.92)
|
0.60
|
-
N number of copies of allele seen in 1378 controls or 225 cases, OR odds ratio, CI confidence interval
- *denotes where HLA-DRB1*04:02 and *04:03 categories were combined because of low numbers
