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Table 2 Allele frequencies and per-allele odds ratios in giant cell arteritis cases and controls

From: Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

HLA-DRB1 allele Allele frequency in controls, N (%) Allele frequency in cases, N (%) Allele frequency in biopsy-positive cases, N (%) Unadjusted OR (95 % CI) P value OR adjusted for *04 (95 % CI) P value
*01 341 (12.4) 27 (6.0) 12 (4.3) 0.46 (0.31, 0.69) 1.6×10−4 0.55 (0.37, 0.83) 0.0046
*03 438 (15.9) 75 (16.7) 41 (14.5) 1.06 (0.81, 1.39) 0.68 1.31 (0.99, 1.74) 0.061
*04 503 (18.3) 138 (30.7) 89 (31.6) 2.03 (1.61, 2.56) 1.7×10−9 - -
*04:01 304 (11.0) 83 (18.4) 54 (19.1) 1.87 (1.42, 2.46) 8.2×10−6 - -
*04:02 10 (0.4) 2 (0.4) 1 (0.4) 1.29 (0.64, 2.59)* 0.48* - -
*04:03 38 (1.4) 8 (1.8) 7 (2.5)
*04:04/04:08 151 (5.5) 45 (10.0) 27 (9.6) 1.86 (1.32, 2.63) 3.7×10−4 - -
*07 393 (14.3) 57 (12.7) 34 (12.1) 0.88 (0.65, 1.17) 0.37 1.03 (0.76, 1.39) 0.85
*08 78 (2.8) 8 (1.8) 4 (1.4) 0.62 (0.30, 1.29) 0.20 0.75 (0.36, 1.57) 0.45
*09 30 (1.1) 5 (1.1) 5 (1.8) 1.02 (0.39, 2.66) 0.97 1.19 (0.45, 3.12) 0.73
*10 21 (0.8) 0 (0.0) 0 (0.0) - - -  
*11 179 (6.5) 32 (7.1) 20 (7.1) 1.09 (0.75, 1.59) 0.64 1.25 (0.86, 1.83) 0.25
*12 49 (1.8) 10 (2.2) 6 (2.1) 1.24 (0.64, 2.42) 0.53 1.60 (0.81, 3.14) 0.18
*13 222 (8.1) 41 (9.1) 32 (11.3) 1.14 (0.81, 1.62) 0.45 1.35 (0.95, 1.93) 0.098
*14 60 (2.2) 10 (2.2) 5 (1.7) 1.02 (0.52, 2.00) 0.95 1.29 (0.65, 2.56) 0.46
*15 421 (15.3) 45 (10.0) 32 (11.3) 0.63 (0.46, 0.87) 0.0047 0.75 (0.54, 1.04) 0.085
*16 21 (0.8) 2 (0.4) 2 (0.7) 0.58 (0.13, 2.49) 0.46 0.67 (0.16, 2.92) 0.60
  1. N number of copies of allele seen in 1378 controls or 225 cases, OR odds ratio, CI confidence interval
  2. *denotes where HLA-DRB1*04:02 and *04:03 categories were combined because of low numbers