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Table 2 Allele frequencies and per-allele odds ratios in giant cell arteritis cases and controls
| HLA-DRB1 allele | Allele frequency in controls, N (%) | Allele frequency in cases, N (%) | Allele frequency in biopsy-positive cases, N (%) | Unadjusted OR (95 % CI) | P value | OR adjusted for *04 (95 % CI) | P value |
|---|---|---|---|---|---|---|---|
| *01 | 341 (12.4) | 27 (6.0) | 12 (4.3) | 0.46 (0.31, 0.69) | 1.6×10−4 | 0.55 (0.37, 0.83) | 0.0046 |
| *03 | 438 (15.9) | 75 (16.7) | 41 (14.5) | 1.06 (0.81, 1.39) | 0.68 | 1.31 (0.99, 1.74) | 0.061 |
| *04 | 503 (18.3) | 138 (30.7) | 89 (31.6) | 2.03 (1.61, 2.56) | 1.7×10−9 | - | - |
| *04:01 | 304 (11.0) | 83 (18.4) | 54 (19.1) | 1.87 (1.42, 2.46) | 8.2×10−6 | - | - |
| *04:02 | 10 (0.4) | 2 (0.4) | 1 (0.4) | 1.29 (0.64, 2.59)* | 0.48* | - | - |
| *04:03 | 38 (1.4) | 8 (1.8) | 7 (2.5) | ||||
| *04:04/04:08 | 151 (5.5) | 45 (10.0) | 27 (9.6) | 1.86 (1.32, 2.63) | 3.7×10−4 | - | - |
| *07 | 393 (14.3) | 57 (12.7) | 34 (12.1) | 0.88 (0.65, 1.17) | 0.37 | 1.03 (0.76, 1.39) | 0.85 |
| *08 | 78 (2.8) | 8 (1.8) | 4 (1.4) | 0.62 (0.30, 1.29) | 0.20 | 0.75 (0.36, 1.57) | 0.45 |
| *09 | 30 (1.1) | 5 (1.1) | 5 (1.8) | 1.02 (0.39, 2.66) | 0.97 | 1.19 (0.45, 3.12) | 0.73 |
| *10 | 21 (0.8) | 0 (0.0) | 0 (0.0) | - | - | - | |
| *11 | 179 (6.5) | 32 (7.1) | 20 (7.1) | 1.09 (0.75, 1.59) | 0.64 | 1.25 (0.86, 1.83) | 0.25 |
| *12 | 49 (1.8) | 10 (2.2) | 6 (2.1) | 1.24 (0.64, 2.42) | 0.53 | 1.60 (0.81, 3.14) | 0.18 |
| *13 | 222 (8.1) | 41 (9.1) | 32 (11.3) | 1.14 (0.81, 1.62) | 0.45 | 1.35 (0.95, 1.93) | 0.098 |
| *14 | 60 (2.2) | 10 (2.2) | 5 (1.7) | 1.02 (0.52, 2.00) | 0.95 | 1.29 (0.65, 2.56) | 0.46 |
| *15 | 421 (15.3) | 45 (10.0) | 32 (11.3) | 0.63 (0.46, 0.87) | 0.0047 | 0.75 (0.54, 1.04) | 0.085 |
| *16 | 21 (0.8) | 2 (0.4) | 2 (0.7) | 0.58 (0.13, 2.49) | 0.46 | 0.67 (0.16, 2.92) | 0.60 |
