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Table 2 Allele frequencies and per-allele odds ratios in giant cell arteritis cases and controls

From: Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

HLA-DRB1 allele

Allele frequency in controls, N (%)

Allele frequency in cases, N (%)

Allele frequency in biopsy-positive cases, N (%)

Unadjusted OR (95 % CI)

P value

OR adjusted for *04 (95 % CI)

P value

*01

341 (12.4)

27 (6.0)

12 (4.3)

0.46 (0.31, 0.69)

1.6×10−4

0.55 (0.37, 0.83)

0.0046

*03

438 (15.9)

75 (16.7)

41 (14.5)

1.06 (0.81, 1.39)

0.68

1.31 (0.99, 1.74)

0.061

*04

503 (18.3)

138 (30.7)

89 (31.6)

2.03 (1.61, 2.56)

1.7×10−9

-

-

*04:01

304 (11.0)

83 (18.4)

54 (19.1)

1.87 (1.42, 2.46)

8.2×10−6

-

-

*04:02

10 (0.4)

2 (0.4)

1 (0.4)

1.29 (0.64, 2.59)*

0.48*

-

-

*04:03

38 (1.4)

8 (1.8)

7 (2.5)

*04:04/04:08

151 (5.5)

45 (10.0)

27 (9.6)

1.86 (1.32, 2.63)

3.7×10−4

-

-

*07

393 (14.3)

57 (12.7)

34 (12.1)

0.88 (0.65, 1.17)

0.37

1.03 (0.76, 1.39)

0.85

*08

78 (2.8)

8 (1.8)

4 (1.4)

0.62 (0.30, 1.29)

0.20

0.75 (0.36, 1.57)

0.45

*09

30 (1.1)

5 (1.1)

5 (1.8)

1.02 (0.39, 2.66)

0.97

1.19 (0.45, 3.12)

0.73

*10

21 (0.8)

0 (0.0)

0 (0.0)

-

-

-

 

*11

179 (6.5)

32 (7.1)

20 (7.1)

1.09 (0.75, 1.59)

0.64

1.25 (0.86, 1.83)

0.25

*12

49 (1.8)

10 (2.2)

6 (2.1)

1.24 (0.64, 2.42)

0.53

1.60 (0.81, 3.14)

0.18

*13

222 (8.1)

41 (9.1)

32 (11.3)

1.14 (0.81, 1.62)

0.45

1.35 (0.95, 1.93)

0.098

*14

60 (2.2)

10 (2.2)

5 (1.7)

1.02 (0.52, 2.00)

0.95

1.29 (0.65, 2.56)

0.46

*15

421 (15.3)

45 (10.0)

32 (11.3)

0.63 (0.46, 0.87)

0.0047

0.75 (0.54, 1.04)

0.085

*16

21 (0.8)

2 (0.4)

2 (0.7)

0.58 (0.13, 2.49)

0.46

0.67 (0.16, 2.92)

0.60

  1. N number of copies of allele seen in 1378 controls or 225 cases, OR odds ratio, CI confidence interval
  2. *denotes where HLA-DRB1*04:02 and *04:03 categories were combined because of low numbers