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Table 3 Meta-analysis of HLA-DRB1 giant cell arteritis associations in the literature

From: Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

HLA-DRB1 allele(s)

UK GCA Cohort

Published data only

Combination of data in this report with published data

OR (95 % CI) for carriage of allele

P value

Number of studies

OR (95 % CI) for carriage of allele

Meta-analysis P value

Heterogeneity I2 statistic (%)

Number of studies

OR (95 % CI) for carriage of allele

Meta-analysis P value

Heterogeneity I2 statistic (%)

*01

0.46 (0.30, 0.70)

0.00033

14

0.78 (0.57, 1.06)

0.11

39.4

15

0.73 (0.54, 0.98)

0.037

48.1

DR2 (*15 and *16)

0.53 (0.37, 0.76)

0.00050

13

0.71 (0.57, 0.88)

0.0019

0

14

0.65 (0.54, 0.79)

8.2×10−6

0

*03

1.12 (0.83, 1.52)

0.47

14

1.02 (0.81, 1.28)

0.87

10.0

15

1.05 (0.88, 1.27)

0.58

4.2

*04

2.69 (2.02, 3.58)

1.5×10−11

15

2.45 (2.06, 2.92)

9.2×10−24

0

16

2.51 (2.16, 2.92)

1.1×10−33

0

*05 (*11 and *12)

1.21 (0.83, 1.75)

0.32

9

0.85 (0.65, 1.12)

0.24

0

10

0.96 (0.77, 1.20)

0.72

0

*06 (*13 and *14)

1.11 (0.78, 1.57)

0.56

10

0.69 (0.48, 0.99)

0.042

27.1

11

0.76 (0.55, 1.06)

0.11

40.6

*07

0.92 (0.66, 1.28)

0.63

14

1.14 (0.81, 1.60)

0.45

65.0

15

1.12 (0.83, 1.50)

0.47

63.4

*11

1.18 (0.78, 1.79)

0.43

6

0.90 (0.65, 1.26)

0.55

6.9

7

1.00 (0.77, 1.30)

0.98

5.1

*13

1.15 (0.79, 1.68)

0.47

5

0.68 (0.47, 1.00)

0.050

0

6

0.89 (0.68, 1.16)

0.39

0

  1. GCA giant cell arteritis, OR odds ratio, CI confidence interval
  2. Insufficient data were present for HLA-DRB1*08, *09, *10, *12, *14, *15 and *16 to perform meta-analysis. Published studies included in this meta-analysis for each allele were HLA-DRB1*01/*03/*07 [13, 36–48], HLA-DRB1*02 [13, 36–46, 48], HLA-DRB1*05 [13, 36–39, 41–43, 46], HLA-DRB1*06 [13, 36–39, 41–44, 46], HLA-DRB1*11 [13, 40, 44, 45, 47, 48], and HLA-DRB1*13 [13, 40, 45, 47, 48]