HLA-DRB1 allele(s) | UK GCA Cohort | Published data only | Combination of data in this report with published data | |||||||
---|---|---|---|---|---|---|---|---|---|---|
OR (95 % CI) for carriage of allele | P value | Number of studies | OR (95 % CI) for carriage of allele | Meta-analysis P value | Heterogeneity I2 statistic (%) | Number of studies | OR (95 % CI) for carriage of allele | Meta-analysis P value | Heterogeneity I2 statistic (%) | |
*01 | 0.46 (0.30, 0.70) | 0.00033 | 14 | 0.78 (0.57, 1.06) | 0.11 | 39.4 | 15 | 0.73 (0.54, 0.98) | 0.037 | 48.1 |
DR2 (*15 and *16) | 0.53 (0.37, 0.76) | 0.00050 | 13 | 0.71 (0.57, 0.88) | 0.0019 | 0 | 14 | 0.65 (0.54, 0.79) | 8.2×10−6 | 0 |
*03 | 1.12 (0.83, 1.52) | 0.47 | 14 | 1.02 (0.81, 1.28) | 0.87 | 10.0 | 15 | 1.05 (0.88, 1.27) | 0.58 | 4.2 |
*04 | 2.69 (2.02, 3.58) | 1.5×10−11 | 15 | 2.45 (2.06, 2.92) | 9.2×10−24 | 0 | 16 | 2.51 (2.16, 2.92) | 1.1×10−33 | 0 |
*05 (*11 and *12) | 1.21 (0.83, 1.75) | 0.32 | 9 | 0.85 (0.65, 1.12) | 0.24 | 0 | 10 | 0.96 (0.77, 1.20) | 0.72 | 0 |
*06 (*13 and *14) | 1.11 (0.78, 1.57) | 0.56 | 10 | 0.69 (0.48, 0.99) | 0.042 | 27.1 | 11 | 0.76 (0.55, 1.06) | 0.11 | 40.6 |
*07 | 0.92 (0.66, 1.28) | 0.63 | 14 | 1.14 (0.81, 1.60) | 0.45 | 65.0 | 15 | 1.12 (0.83, 1.50) | 0.47 | 63.4 |
*11 | 1.18 (0.78, 1.79) | 0.43 | 6 | 0.90 (0.65, 1.26) | 0.55 | 6.9 | 7 | 1.00 (0.77, 1.30) | 0.98 | 5.1 |
*13 | 1.15 (0.79, 1.68) | 0.47 | 5 | 0.68 (0.47, 1.00) | 0.050 | 0 | 6 | 0.89 (0.68, 1.16) | 0.39 | 0 |