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Table 3 Meta-analysis of HLA-DRB1 giant cell arteritis associations in the literature

From: Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

HLA-DRB1 allele(s) UK GCA Cohort Published data only Combination of data in this report with published data
OR (95 % CI) for carriage of allele P value Number of studies OR (95 % CI) for carriage of allele Meta-analysis P value Heterogeneity I2 statistic (%) Number of studies OR (95 % CI) for carriage of allele Meta-analysis P value Heterogeneity I2 statistic (%)
*01 0.46 (0.30, 0.70) 0.00033 14 0.78 (0.57, 1.06) 0.11 39.4 15 0.73 (0.54, 0.98) 0.037 48.1
DR2 (*15 and *16) 0.53 (0.37, 0.76) 0.00050 13 0.71 (0.57, 0.88) 0.0019 0 14 0.65 (0.54, 0.79) 8.2×10−6 0
*03 1.12 (0.83, 1.52) 0.47 14 1.02 (0.81, 1.28) 0.87 10.0 15 1.05 (0.88, 1.27) 0.58 4.2
*04 2.69 (2.02, 3.58) 1.5×10−11 15 2.45 (2.06, 2.92) 9.2×10−24 0 16 2.51 (2.16, 2.92) 1.1×10−33 0
*05 (*11 and *12) 1.21 (0.83, 1.75) 0.32 9 0.85 (0.65, 1.12) 0.24 0 10 0.96 (0.77, 1.20) 0.72 0
*06 (*13 and *14) 1.11 (0.78, 1.57) 0.56 10 0.69 (0.48, 0.99) 0.042 27.1 11 0.76 (0.55, 1.06) 0.11 40.6
*07 0.92 (0.66, 1.28) 0.63 14 1.14 (0.81, 1.60) 0.45 65.0 15 1.12 (0.83, 1.50) 0.47 63.4
*11 1.18 (0.78, 1.79) 0.43 6 0.90 (0.65, 1.26) 0.55 6.9 7 1.00 (0.77, 1.30) 0.98 5.1
*13 1.15 (0.79, 1.68) 0.47 5 0.68 (0.47, 1.00) 0.050 0 6 0.89 (0.68, 1.16) 0.39 0
  1. GCA giant cell arteritis, OR odds ratio, CI confidence interval
  2. Insufficient data were present for HLA-DRB1*08, *09, *10, *12, *14, *15 and *16 to perform meta-analysis. Published studies included in this meta-analysis for each allele were HLA-DRB1*01/*03/*07 [13, 3648], HLA-DRB1*02 [13, 3646, 48], HLA-DRB1*05 [13, 3639, 4143, 46], HLA-DRB1*06 [13, 3639, 4144, 46], HLA-DRB1*11 [13, 40, 44, 45, 47, 48], and HLA-DRB1*13 [13, 40, 45, 47, 48]