Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

Mackie, Sarah Louise; Taylor, John C.; Haroon-Rashid, Lubna; Martin, Stephen; Dasgupta, Bhaskar; Gough, Andrew; Green, Michael; Hordon, Lesley; Jarrett, Stephen; Pease, Colin T.; Barrett, Jennifer H.; Watts, Richard; Morgan, Ann W.

doi:10.1186/s13075-015-0692-4

Table 4 Incidence of giant cell arteritis and population HLA-DRB1 allele frequencies in different countries

From: Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

GCA incidence study					HLA-DRB1 allele frequency and references (if multiple references given, the allele frequency is the weighted mean)
City/region, country, reference	Dates, study design	GCA criteria	GCA incidence, per 100,000 per year in over-50s	Latitude (degrees N)	*04	*01	*15	*04:01	*04:04
W Nyland, Finland [49]	1987-88, prospective	Biopsy, clinical	26.2	61.5	0.147 (n = 1157 [50])	0.183 (n = 1157 [50])	0.144 (n = 1157 [50])	0.080 (n = 1157 [50])	0.037 (n = 1157 [50])
Goteborg, Sweden [51]	1976-95, retrospective	Biopsy, clinical	22.2	57.7	0.195 (n = 1347 [22], 1366 [52], 1209 [53], 1191 [54])	0.105 (n = 1347 [22], 1366 [52], 1209 [53], 1191 [54])	0.159 (n = 1347 [22], 1366 [52], 1209 [53], 1191 [54])	0.137 (n = 934 [55], 1763 [56], 1191 [54])	0.057 (n = 934 [55], 1763 [56], 1191 [54])
Reggio Emilia, Italy [57]	1980-88, retrospective	Biopsy	6.9	44.7	0.072 (n = 57,345 [58], 4080 [22], 2054 [22], 1992 [59])	0.089 (n = 57,345 [58], 4080 [22], 2054 [22], 1992 [59])	0.068 (n = 57,345 [58], 2054 [22], 1992 [59])	0.017 (n = 57,345 [58])	0.012 (n = 57345 [58])
Lugo, NW Spain [60]	1981-98, retrospective	Biopsy	10.2	43.0	0.129 (n = 1940 [61], 1088 [62])	0.103 (n = 1940 [61], 1088 [62])	0.104 (n = 1940 [61], 1088 [62])	0.053 (n = 145 [22])	0.0207 (n = 145 [22])
Denmark [63]	1982-94, prospective	Biopsy	20.4	56.5	0.180 (n = 562 [64])	0.101 (n = 562 [64])	0.157 (n = 562 [64])	0.176 (n = 55 [22])	0.001 (n = 55 [22])
Iceland [65]	1984-90, retrospective	ACR 1990 criteria	27.0	64.7	0.170 (n = 172 [66])	0.040 (n = 172 [66])	0.020 (n = 172 [66])	No data	No data
Alesund and Bodo, Norway [67]	1992-6, retrospective, hospital	Biopsy/ACR 1990 criteria	32.4	64.9	0.225 (n = 576 [22], 630 [68], 368 [69], 898 [55])	0.117 (n = 576 [22], 630 [68], 898 [55])	0.153 (n = 576 [22], 630 [68], 368 [69], 898 [55])	0.117 (n = 898 [55])	0.067 (n = 898 [55])
Schleswig Holstein, North Germany [70]	1998-2002, prospective, population	Chapel Hill consensus criteria	3.2	54.2	0.140 (n = 11,407 [22], 8862 [22], 4251 [71])	0.111 (n = 11,407 [22], 8862 [22], 4251 [71])	0.141 (n = 11,407 [22], 8862 [22], 4251 [71])	0.081 (n = 8862 [22])	0.024 (n = 8862 [22])
Vilnius, Lithuania [72]	1990-9, prospective, hospital	ACR 1990 criteria	0.7	54.7	0.078 (n = 134 [73])	0.111 (n = 134 [73])	No data	No data	No data
Jerusalem [74]	1980-2004, retrospective	Biopsy + ACR 1990 criteria	11.3	31.8	0.170 (n = 23000 [22])	0.083 (n = 23,000 [22])	0.070 (n = 23,000 [22])	0.019 (n = 132 [75])	0.015 (n = 132 [75])
Sephardic Jews, Israel [76]	1980-91, retrospective	Biopsy	10.2	31.8	0.112 (n = 293 [77])	0.038 (n = 293 [77])	0.087 (n = 293 [77])	0.000 (n = 293 [77])	0.009 (n = 293 [77])
UK [28]	1990-2001, prospective	Clinical	22.0	51.5	0.204 (n = 39,979 [22], 1238 [78])	0.110 (n = 39,979 [22], 1238 [78])	0.143 (n = 39,979 [22], 1238 [78])	0.116 (n = 298 [22])	0.047 (n = 298 [22])
Erdirne, Turkey [79]	2003-9, retrospective	Clinical	1.1	41.7	0.128 (n = 250 [22], 253 [80], 250 [81])	0.047 (n = 250 [22], 253 [80], 250 [81])	0.082 (n = 250 [22], 253 [80], 250 [81])	0.014 (n = 110 [82], 250 [81])	0.019 (n = 110 [82], 250 [81])
Olmsted County, MN, USA [83]	2000-2004, prospective, population	ACR 1990	18.9	44.0	0.156 (n = 339 [22])	0.097 (n = 339 [22])	0.124 (n = 339 [22])	0.091 (n = 339 [22])	0.040 (n = 339 [22])
White, Memphis, TN, USA [84]	1971-1980, retrospective	Biopsy/clinical	2.2	35.2	0.156 (n = 61,655 [22])	0.110 (n = 61,655 [22])	0.133 (n = 61,655 [22])	0.091 (n = 61,655 [22])	0.031 (n = 61,655 [22])
Black, Memphis, TN, USA [84]	1971-1980, retrospective	Biopsy/clinical	0.4	35.2	0.060 (n = 34 [85])	No data	0.210 (n = 34 [85])	No data	No data
Europeans, Saskatoon, Canada [86]	1998-2003, prospective	Biopsy	9.3	52.1	0.178 (n = 415 [87])	0.092 (n = 415 [87])	0.147 (n = 415 [87])	0.097 (n = 216 [88])	0.051 (n = 216 [88])

ACR American College of Rheumatology
Giant cell arteritis (GCA) incidence in Finland was taken as weighted mean of the two sub-studies reported in the article cited. Allele frequencies are the weighted mean of the allele frequencies reported in the studies cited (see Methods for details of how these were selected). For brevity, where the data were taken from the allelefrequencies.net website, the main citation for the website is given [22]; searching allelefrequencies.net on the country, sample size, and human leukocyte antigen (HLA) allele in question will give the allele frequencies used in this table

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