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Table 5 Results of tests for association of amino acid at the most significant positions: 9, 11, 13, 33, and 37

From: Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation

Position in HLA-DRB1 Amino acid residue Frequency Univariable Stepwise model (entry P = 0.05) applied separately at each position
Cases Controls OR P value OR P value
9 E 0.698 0.565 1.78 7.3×10−8   
K 0.011 0.011 1.03 0.96   
W 0.291 0.424 0.56 5.8×10−8 0.56 5.85×10−8
11 D 0.011 0.011 1.03 0.96   
G 0.127 0.142 0.88 0.38   
L 0.060 0.123 0.46 3.6×10−5 0.64 0.040
P 0.104 0.159 0.63 0.0024   
S 0.391 0.371 1.09 0.41 1.37 0.015
V 0.307 0.194 1.86 1.4×10−7 2.06 2.8×10−7
13 F 0.071 0.141 0.48 1.7×10−5 0.66 0.038
G 0.040 0.045 0.87 0.60   
H 0.307 0.187 1.96 1.5×10−8 2.11 5.5×10−8
R 0.104 0.159 0.63 0.0024   
S 0.351 0.325 1.12 0.28 1.38 0.014
Y 0.127 0.142 0.88 0.38   
33 H 0.307 0.187 1.96 1.5×10−8 1.96 1.527×10−8
N 0.693 0.813 0.51 1.5×10−8   
37 F 0.147 0.161 0.89 0.39   
L 0.022 0.017 1.27 0.49   
N 0.256 0.219 1.09 0.46   
S 0.164 0.282 0.51 8.0×10−8 0.59 0.00012
Y 0.402 0.276 1.63 3.2×10−6 1.37 0.0055
  1. Forward stepwise regression was used to determine whether there are independent effects of more than one amino acid residue at the same position. Only amino acids that were retained by the stepwise regression model are shown in the last two columns. Odds ratio (OR) of less than 1.0 indicates a protective effect, whereas OR of more than 1.0 indicates a susceptibility effect. Note the high level of linkage disequilibrium at this locus; Additional file 1 shows the amino acid residues within the three hypervariable regions of HLA-DRB1