|
Position in HLA-DRB1
|
Amino acid residue
|
Frequency
|
Univariable
|
Stepwise model (entry P = 0.05) applied separately at each position
|
|---|
|
Cases
|
Controls
|
OR
|
P value
|
OR
|
P value
|
|---|
|
9
|
E
|
0.698
|
0.565
|
1.78
|
7.3×10−8
| | |
|
K
|
0.011
|
0.011
|
1.03
|
0.96
| | |
|
W
|
0.291
|
0.424
|
0.56
|
5.8×10−8
|
0.56
|
5.85×10−8
|
|
11
|
D
|
0.011
|
0.011
|
1.03
|
0.96
| | |
|
G
|
0.127
|
0.142
|
0.88
|
0.38
| | |
|
L
|
0.060
|
0.123
|
0.46
|
3.6×10−5
|
0.64
|
0.040
|
|
P
|
0.104
|
0.159
|
0.63
|
0.0024
| | |
|
S
|
0.391
|
0.371
|
1.09
|
0.41
|
1.37
|
0.015
|
|
V
|
0.307
|
0.194
|
1.86
|
1.4×10−7
|
2.06
|
2.8×10−7
|
|
13
|
F
|
0.071
|
0.141
|
0.48
|
1.7×10−5
|
0.66
|
0.038
|
|
G
|
0.040
|
0.045
|
0.87
|
0.60
| | |
|
H
|
0.307
|
0.187
|
1.96
|
1.5×10−8
|
2.11
|
5.5×10−8
|
|
R
|
0.104
|
0.159
|
0.63
|
0.0024
| | |
|
S
|
0.351
|
0.325
|
1.12
|
0.28
|
1.38
|
0.014
|
|
Y
|
0.127
|
0.142
|
0.88
|
0.38
| | |
|
33
|
H
|
0.307
|
0.187
|
1.96
|
1.5×10−8
|
1.96
|
1.527×10−8
|
|
N
|
0.693
|
0.813
|
0.51
|
1.5×10−8
| | |
|
37
|
F
|
0.147
|
0.161
|
0.89
|
0.39
| | |
|
L
|
0.022
|
0.017
|
1.27
|
0.49
| | |
|
N
|
0.256
|
0.219
|
1.09
|
0.46
| | |
|
S
|
0.164
|
0.282
|
0.51
|
8.0×10−8
|
0.59
|
0.00012
|
|
Y
|
0.402
|
0.276
|
1.63
|
3.2×10−6
|
1.37
|
0.0055
|
- Forward stepwise regression was used to determine whether there are independent effects of more than one amino acid residue at the same position. Only amino acids that were retained by the stepwise regression model are shown in the last two columns. Odds ratio (OR) of less than 1.0 indicates a protective effect, whereas OR of more than 1.0 indicates a susceptibility effect. Note the high level of linkage disequilibrium at this locus; Additional file 1 shows the amino acid residues within the three hypervariable regions of HLA-DRB1
