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Table 2 Relationship between different parameters and histopathologic grade

From: Clinicopathological characteristics of immunoglobulin G4-related sialadenitis

    Histopathologic grade  
    I II III P
    (n = 14) (n = 14) (n = 14)  
Clinical features       
  Male/female   3: 4 3: 11 1:1  
  Age (years)   54.1 52.0 57.4 0.539
  Volumes of swollen salivary glands PG 39.65 ± 8.15 38.68 ± 10.9 34.56 ± 6.03 0.223
   SMG 14.52 ± 2.00 16.31 ± 3.40 16.23 ± 2.64 0.068
Serologic examinations       
  IgG (mg/dl)   15776.4 ± 6304.9 15838.0 ± 3993.0 26226.7 ± 9820.8 0.001
  IgG2 (mg/dl)   539.6 ± 225.3 510.8 ± 195.2 531.7 ± 221.8 0.935
  IgG4 (mg/dl)   647.8 ± 700.1 818.6 ± 894.1 1802.8 ± 1011.0 0.002
  T-IgE (KU/U)   626.4 ± 705.5 361.9 ± 401.8 372.2 ± 344.2 0.433
  EOS (%)   4.7 ± 3.3 3.6 ± 3.4 4.8 ± 3.6 0.638
  (IgG1 + IgG3) / (IgG2 + IgG4) (%)   88.3 ± 48.7 70.6 ± 23.0 47.2 ± 17.5 0.007
Immunohistochemical examinations IgG4+ (cells/HPF)   90 ± 27 134 ± 33 143 ± 43 0.001
  IgG+ (cells/HPF)   133 ± 37 172 ± 37 191 ± 42 0.001
  IgG4+/IgG+ (%)   68.7 ± 12.2 78.0 ± 9.8 74.0 ± 13.2 0.125
  EOS (cells/HPF)   23 ± 22 17 ± 7 11 ± 7 0.097
Flow rate of whole saliva Rest (g/5 minutes)   1.04 ± 0.72 1.04 ± 1.27 0.82 ± 0.51 0.757
  Stimulated (g/5 minutes)   10.11 ± 3.23 8.12 ± 4.24 6.78 ± 2.57 0.045
Scintigraphy CI (%) PG 74.22 ± 9.12 77.02 ± 10.77 67.26 ± 11.00 0.094
   SMG 53.29 ± 12.54 49.05 ± 9.10 34.20 ± 9.26 <0.001
  SI (%) PG 47.33 ± 15.10 52.14 ± 10.15 46.90 ± 14.50 0.603
   SMG 38.50 ± 17.50 27.12 ± 9.70 26.1 ± 8.50 0.055
  1. CI concentration index, EOS eosinophil, HPF high power field, PG parotid gland, SI secretion index, SMG submandibular gland, T-IgE total immunoglobulin E