Table 2 Relationship between different parameters and histopathologic grade

Clinical features

Male/female

3: 4

3: 11

1:1

Age (years)

54.1

52.0

57.4

0.539

Volumes of swollen salivary glands

PG

39.65 ± 8.15

38.68 ± 10.9

34.56 ± 6.03

0.223

SMG

14.52 ± 2.00

16.31 ± 3.40

16.23 ± 2.64

0.068

Serologic examinations

IgG (mg/dl)

15776.4 ± 6304.9

15838.0 ± 3993.0

26226.7 ± 9820.8

0.001

IgG2 (mg/dl)

539.6 ± 225.3

510.8 ± 195.2

531.7 ± 221.8

0.935

IgG4 (mg/dl)

647.8 ± 700.1

818.6 ± 894.1

1802.8 ± 1011.0

0.002

T-IgE (KU/U)

626.4 ± 705.5

361.9 ± 401.8

372.2 ± 344.2

0.433

EOS (%)

4.7 ± 3.3

3.6 ± 3.4

4.8 ± 3.6

0.638

(IgG1 + IgG3) / (IgG2 + IgG4) (%)

88.3 ± 48.7

70.6 ± 23.0

47.2 ± 17.5

0.007

Immunohistochemical examinations

IgG4⁺ (cells/HPF)

90 ± 27

134 ± 33

143 ± 43

0.001

IgG⁺ (cells/HPF)

133 ± 37

172 ± 37

191 ± 42

0.001

IgG4⁺/IgG⁺ (%)

68.7 ± 12.2

78.0 ± 9.8

74.0 ± 13.2

0.125

EOS (cells/HPF)

23 ± 22

17 ± 7

11 ± 7

0.097

Flow rate of whole saliva

Rest (g/5 minutes)

1.04 ± 0.72

1.04 ± 1.27

0.82 ± 0.51

0.757

Stimulated (g/5 minutes)

10.11 ± 3.23

8.12 ± 4.24

6.78 ± 2.57

0.045

Scintigraphy

CI (%)

PG

74.22 ± 9.12

77.02 ± 10.77

67.26 ± 11.00

0.094

SMG

53.29 ± 12.54

49.05 ± 9.10

34.20 ± 9.26

<0.001

SI (%)

PG

47.33 ± 15.10

52.14 ± 10.15

46.90 ± 14.50

0.603

SMG

38.50 ± 17.50

27.12 ± 9.70

26.1 ± 8.50

0.055