Fig. 2

CAIA results in trabecular, but not cortical, bone loss. C57BL/6 mice were ovariectomized and subjected to LPS + collagen antibodies (CAIA) or LPS alone (control). The experiment was terminated 9 days after arthritis induction. a Trabecular bone volume as percent of tissue volume (BV/TV) (**p = 0.005), b trabecular thickness (Tb.Th) (**p = 0.006), c trabecular number (Tb.N) (*p = 0.011), and d trabecular separation (Tb.Sp) (*p = 0.024) in the distal metaphyseal region as well as e cortical thickness (Ct.Th) (p = 0.358) in the diaphyseal region of femur was analyzed by μCT in CAIA (n = 7) and control (n = 7) mice. Student’s t test a–e, on log data a, b, c, e. CAIA collagen-antibody induced arthritis, LPS lipopolysaccharide