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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes

Fig. 1

Expression of canonical BMP signaling components in RA synoviocytes. Synoviocytes grown from synovial tissue samples obtained from patients with RA were used between passages 4 and 9 to study the expression of several components of the canonical BMP signaling pathway by quantitative reverse transcription-polymerase chain reaction. Frames show the mRNA levels for a BMP receptors, b BMP ligands, c Smad protein family components, d BMP target genes, and e BMP antagonists. GNB2L1 was used as an endogenous control. Bars represent the mean (± standard deviation) of three to five independent experiments. ACTRIA type IA activin receptor, ACTRIIA type IIA activin receptor, ACTRIIB type IIB activin receptor, BAMBI bone morphogenetic protein and activin membrane-bound inhibitor, BMP bone morphogenetic protein, BMPRIA type IA bone morphogenetic protein receptor, BMPRIB type IB bone morphogenetic protein receptor, BMPRII type II bone morphogenetic protein receptor, Id inhibitor of DNA-binding/differentiation, RA rheumatoid arthritis, Runx Runt-related transcription factor, Smad small mother against decapentaplegic homolog

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