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Table 3 Association of biomarker levels at the early time point with the later diagnosis of pulmonary hypertension

From: Biomarkers of pulmonary hypertension in patients with scleroderma: a case–control study

Biomarker

PH (n = 12)

No PH (n = 21)

p value

IL-5

1.1 (1.0–1.7)

1.0 (0.8–1.7)

0.38

IL-8

17.5 (6.01–153.2)

7.6 (5.2–19.4)

0.20

IL-12

2.9 (2.0–8.2)

1.8 (1.5–3.3)

0.03

TNF-α

7.2 (4.6–22.3)

5.9 (4.3–10.0)

0.50

VEGF

386.7 (183.1–661.6)

388.81 (199.0–498.2)

0.91

bFGF

16.8 (7.1–42.7)

11.8 (6.3–19.5)

0.41

PlGF

24.9 (20.9–26.8)

19.3 (15.1–24.8)

0.07

sFlt-1

124.0 (101.5–138.5)

99.2 (84.2–113.0)

0.02

HGF

249.0 (148.1–568.0)

176.1 (139.2–253.9)

0.18

  1. Abbreviations: bFGF basic fibroblast growth factor, HGF hepatocyte growth factor, IL interleukin, PH pulmonary hypertension, PlGF placental growth factor, sFlt-1 soluble fms-like tyrosine kinase-1, TNF tumor necrosis factor, VEGF vascular endothelial growth factor
  2. Data are presented as median (interquartile range) in picograms per milliliter