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Table 3 Association of biomarker levels at the early time point with the later diagnosis of pulmonary hypertension

From: Biomarkers of pulmonary hypertension in patients with scleroderma: a case–control study

Biomarker PH (n = 12) No PH (n = 21) p value
IL-5 1.1 (1.0–1.7) 1.0 (0.8–1.7) 0.38
IL-8 17.5 (6.01–153.2) 7.6 (5.2–19.4) 0.20
IL-12 2.9 (2.0–8.2) 1.8 (1.5–3.3) 0.03
TNF-α 7.2 (4.6–22.3) 5.9 (4.3–10.0) 0.50
VEGF 386.7 (183.1–661.6) 388.81 (199.0–498.2) 0.91
bFGF 16.8 (7.1–42.7) 11.8 (6.3–19.5) 0.41
PlGF 24.9 (20.9–26.8) 19.3 (15.1–24.8) 0.07
sFlt-1 124.0 (101.5–138.5) 99.2 (84.2–113.0) 0.02
HGF 249.0 (148.1–568.0) 176.1 (139.2–253.9) 0.18
  1. Abbreviations: bFGF basic fibroblast growth factor, HGF hepatocyte growth factor, IL interleukin, PH pulmonary hypertension, PlGF placental growth factor, sFlt-1 soluble fms-like tyrosine kinase-1, TNF tumor necrosis factor, VEGF vascular endothelial growth factor
  2. Data are presented as median (interquartile range) in picograms per milliliter