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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments

Fig. 5

Chondrocytes from protein kinase C delta (PKC-δ)−/− mice have defective proliferation and matrix production in vitro compared to chondrocytes from PKC-δ+/+ mice. a Low magnification scanned images of alcian blue-stained PKC-δ+/+ and PKC-δ−/− chondrocyte micromass cultures. b 100× magnified images showing the difference in the area of alcian blue staining in PKC-δ+/+ versus PKC-δ−/− chondrocyte micromass cultures (scale bar 100μm). c Analysis of alcian blue staining area in PKC-δ+/+ and PKC-δ−/− micromass cultures relative to PKC-δ+/+ (n = 5, ***p < 0.001). d Analysis of cell numbers in PKC-δ+/+ and PKCδ−/− micromass cultures relative to PKC-δ+/+ (n = 5, *p < 0.05). e Analysis of alcian blue staining area per cell in PKC-δ+/+ and PKC-δ−/− relative to in PKC-δ+/+ (n = 5, *p < 0.05)

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