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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources

Fig. 2

Sera from patients with systemic lupus erythematosus (SLE) had decreased ability to degrade multiple forms of chromatin. a-c Sera from 66 patients with SLE were used to determine degradation of neutrophil extracellular trap (NET) (a), primary (Prim-Nec) (b), and secondary (Sec-Nec) necrotic cell chromatin (c) in comparison to controls (Healthy ctrl) (a, n = 77; b, n = 50; c, n = 66). A cutoff below 2 SD below the mean degradation in the control group defined patients with low degrading ability and is indicated by the dotted line. d Principal component analysis for correlation revealed that degradation of secondary necrotic chromatin and NETs co-correlated. a-c Mean of three independent experiments with an average SD of 5 %. Significance of difference in (a-c) was calculated using the Mann-Whitney test; ***p <0.001; *p <0.05. NHS normal human serum

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