Table 2 SLEDAI-qualifying manifestations are associated with decreased ability to degrade chromatin from multiple sources
Manifestation | Total | NET | Primary necrotic chromatin | Secondary necrotic chromatin |
|---|---|---|---|---|
n = 20/46 | n = 41/25 | n = 9/56 | ||
(% low/% normal) | (% low/% normal) | (% low/% normal) | ||
Seizure | 0 | 0/0 | 0/0 | 0/0 |
Psychosis | 0 | 0/0 | 0/0 | 0/0 |
Organic brain syndrome | 0 | 0/0 | 0/0 | 0/0 |
Visual disturbance | 1 | 0/2.2 | 2.4/0 | 0/1.8 |
Lupus headache | 0 | 0/0 | 0/0 | 0/0 |
Cerebrovascular accident | 0 | 0/0 | 0/0 | 0/0 |
Vasculitis | 5 | 15/4.4 | 4.9/12 | 11/7.2 |
Arthritis | 8 | 10/13 | 12/12 | 11/13 |
Myositis | 1 | 5/0 | 2.4/0 | 11/0* |
Glomerulonephritis | ||||
Cylenduria | 5 | 15/4.4 | 9.8/4 | 11/7 |
Hematuria | 10 | 20/13 | 17/12 | 33/13 |
Proteinuria | 13 | 30/15 | 22/16 | 44/16* |
Pyuria | 5 | 20/2.2* | 9.8/4 | 22/5.4 |
Rash | 10 | 15/15 | 15/16 | 11/16 |
Alopecia | 9 | 20/11 | 20/4 | 22/13 |
Mucosal ulcers | 8 | 15/11 | 17/4 | 22/11 |
Pleuritis | 3 | 5/4.4 | 4.9/4 | 11/3.6 |
Pericarditis | 0 | 0/0 | 0/0 | 0/0 |
Low complement | 23 | 35/35 | 39/28 | 56/30 |
dsDNA antibodies | 22 | 75/15*** | 41/20 | 67/27* |
Fever | 4 | 5/6.5 | 9.8/0* | 0/7.1 |
Thrombocytopenia | 0 | 0/0 | 0/0 | 0/0 |
Leukopenia | 4 | 5/6.5 | 4.9/8 | 0/7.1 |