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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model

Fig. 3

a Schematic diagram of the formation of stable hybrid hydrogels. Positively charged layered double hydroxides (LDH) in a pNIPAAM solution (pNIPAAM chain) transit from a low-viscous state to a stable hydrogel due to hydrophobic interactions between the isopropyl groups of pNIPAAM upon increasing temperature. The celecoxib (CXB) is present in the hydrogel in small crystals, forming a depot, from which dissolution and diffusion takes place. b At 37 °C gelation occurs within 10 s. c One month after intradiscal injection the pNIPAAM MgFe-LDH hydrogel (white arrow) is visible in the nucleus pulposus (NP; **). The annulus fibrosus (AF) is indicated with a black arrow. LDH layered double hydroxide, pNIPAAM poly-N-isopropylacrylamide

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