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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model

Fig. 6

Representative macroscopic and histopathologic image stained with alcian blue/picrosirius red of an IVD treated with NaCl (a) and GAG and PGE2 levels normalized for DNA in nucleus pulposus (NP) and annulus fibrosus (AF) tissue (b-c). The NP in figure (a) has a bulging aspect due to the processing method. b GAG/DNA levels were significantly higher in the NP than in the AF in all treatments. c In all treatments PGE2/DNA levels were significantly lower in the NP than those in the AF. Data are expressed as mean values ± standard deviation. Treatments: NaCl = NaCl (sham); CXB 7.7 μM = celecoxib bolus; CR = unloaded pNIPAAM MgFe-LDH hydrogel; CR + CXB 7.7 μM = pNIPAAM MgFe-LDH hydrogel loaded with 7.7 μM CXB; CR + 77 μM = pNIPAAM MgFe-LDH hydrogel loaded with 77 μM CXB; CR + CXB 770 μM = pNIPAAM MgFe-LDH hydrogel loaded with 770 μM CXB). *Indicates significant difference at a 99 % confidence level. CXB celecoxib, GAG glycosaminoglycan, IVD intervertebral disc, LDH layered double hydroxide, PGE 2 prostaglandin E2, pNIPAAM poly-N-isopropylacrylamide

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