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Table 1 Relationship between the frequencies of microchimeric versus autologous cells of a given immunophenotype

From: Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy

Phenotype JIIM MD NIC
% Autologous CD3+ cells of total autologousa 6.5 ± 2.3 9.9 ± 2.5 4.8 ± 2.7
% Microchimeric CD3+ cells of total microchimeric cellsb 0.3 ± 0.3 2.8 ± 1.8 10 ± 10
  p = 0.06 (T) p = 0.04 p = 0.05
% Autologous CD4 cells of total autologous cells 16.8 ± 6.9 12.2 ± 5.3 8.4 ± 6.6
% Microchimeric CD4 cells of total microchimeric cells 2.2 ± 1.4 7.8 ± 2.0 0 ± 0
  p = 0.03 p = 0.23 p = 0.12
% Autologous CD8 cells of total autologous cells 20.4 ± 5.0 12.6 ± 3.2 5.1 ± 3.2
% Microchimeric CD8 cells of total microchimeric cells 1.1 ± 0.6 6.5 ± 2.3 0 ± 0
  p = 0.05 p = 0.09 p = 0.07
% Autologous Class II cells of total autologous cells 21.5 ± 8.1 51.6 ± 5.9 38.0 ± 11.0
% Microchimeric Class II cells of total microchimeric cells 1.7 ± 1.1 0.8 ± 0.7 20.0 ± 13.3
  p = 0.04 p < 0.001 p = 0.02
% Autologous CD20 cells of total autologous cells 8.5 ± 4.4 2.7 ± 2.5 0 ± 0
% Microchimeric CD20 cells of total microchimeric cells 0 ± 0 0 ± 0 0 ± 0
  p = 0.08 p = 0.3 p = NA
% Autologous CD83 cells of total autologous cells 0.1 ± 0.1 0.1 ± 0.1 0.2 ± 0.2
% Microchimeric CD83cells of total microchimeric cells 0 ± 0 0 ± 0 0 ± 0
  p = 0.18 p = 0.17 p = 0.17
% Autologous CD25 cells of total autologous cells 16.2 ± 5.1 9.5 ± 3.4 6.4 ± 2.8
% Microchimeric CD25 cells of total microchimeric cells 0 ± 0 7.7 ± 2.9 0 ± 0
  p = 0.01 p = 0.33 p = 0.02
% Autologous CD45RA cells of total autologous cells 2.3 ± 0.9 1.5 ± 0.4 3.2 ± 2.3
% Microchimeric CD45RA cells of total microchimeric cells 1.2 ± 1.1 0.9 ± 0.9 0 ± 0
  p = 0.24 p = 0.26 p = 0.10
% Autologous CD45RO cells of total autologous cells 6.3 ± 2.4 4.1 ± 1.1 9.0 ± 4.4
% Microchimeric CD45RO cells of total microchimeric cells 0 ± 0 0 ± 0 0 ± 0
  p = 0.03 p = 0.003 p = 0.06 (T)
% Autologous CD123 cells of total autologous cells 3.6 ± 1.1 1.9 ± 0.7 26.2 ± 12.2
% Microchimeric CD123 cells of total microchimeric cells 0.04 ± 0.02 0 ± 0 4.4 ± 2.3
  p = 0.04 p = 0.06 (T) p = 0.06 (T)
  1. Data are presented as mean ± standard error of the mean for each group
  2. JIIM juvenile idiopathic inflammatory myopathy, MD muscular dystrophy, NIC noninflammatory controls; NA not available, T trend for significance
  3. aTotal autologous cells consists of all phenotyped cells with XY probes
  4. bTotal microchimeric cells consists of all cells with XX probes