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Table 1 Relationship between the frequencies of microchimeric versus autologous cells of a given immunophenotype

From: Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy

Phenotype

JIIM

MD

NIC

% Autologous CD3+ cells of total autologousa

6.5 ± 2.3

9.9 ± 2.5

4.8 ± 2.7

% Microchimeric CD3+ cells of total microchimeric cellsb

0.3 ± 0.3

2.8 ± 1.8

10 ± 10

 

p = 0.06 (T)

p = 0.04

p = 0.05

% Autologous CD4 cells of total autologous cells

16.8 ± 6.9

12.2 ± 5.3

8.4 ± 6.6

% Microchimeric CD4 cells of total microchimeric cells

2.2 ± 1.4

7.8 ± 2.0

0 ± 0

 

p = 0.03

p = 0.23

p = 0.12

% Autologous CD8 cells of total autologous cells

20.4 ± 5.0

12.6 ± 3.2

5.1 ± 3.2

% Microchimeric CD8 cells of total microchimeric cells

1.1 ± 0.6

6.5 ± 2.3

0 ± 0

 

p = 0.05

p = 0.09

p = 0.07

% Autologous Class II cells of total autologous cells

21.5 ± 8.1

51.6 ± 5.9

38.0 ± 11.0

% Microchimeric Class II cells of total microchimeric cells

1.7 ± 1.1

0.8 ± 0.7

20.0 ± 13.3

 

p = 0.04

p < 0.001

p = 0.02

% Autologous CD20 cells of total autologous cells

8.5 ± 4.4

2.7 ± 2.5

0 ± 0

% Microchimeric CD20 cells of total microchimeric cells

0 ± 0

0 ± 0

0 ± 0

 

p = 0.08

p = 0.3

p = NA

% Autologous CD83 cells of total autologous cells

0.1 ± 0.1

0.1 ± 0.1

0.2 ± 0.2

% Microchimeric CD83cells of total microchimeric cells

0 ± 0

0 ± 0

0 ± 0

 

p = 0.18

p = 0.17

p = 0.17

% Autologous CD25 cells of total autologous cells

16.2 ± 5.1

9.5 ± 3.4

6.4 ± 2.8

% Microchimeric CD25 cells of total microchimeric cells

0 ± 0

7.7 ± 2.9

0 ± 0

 

p = 0.01

p = 0.33

p = 0.02

% Autologous CD45RA cells of total autologous cells

2.3 ± 0.9

1.5 ± 0.4

3.2 ± 2.3

% Microchimeric CD45RA cells of total microchimeric cells

1.2 ± 1.1

0.9 ± 0.9

0 ± 0

 

p = 0.24

p = 0.26

p = 0.10

% Autologous CD45RO cells of total autologous cells

6.3 ± 2.4

4.1 ± 1.1

9.0 ± 4.4

% Microchimeric CD45RO cells of total microchimeric cells

0 ± 0

0 ± 0

0 ± 0

 

p = 0.03

p = 0.003

p = 0.06 (T)

% Autologous CD123 cells of total autologous cells

3.6 ± 1.1

1.9 ± 0.7

26.2 ± 12.2

% Microchimeric CD123 cells of total microchimeric cells

0.04 ± 0.02

0 ± 0

4.4 ± 2.3

 

p = 0.04

p = 0.06 (T)

p = 0.06 (T)

  1. Data are presented as mean ± standard error of the mean for each group
  2. JIIM juvenile idiopathic inflammatory myopathy, MD muscular dystrophy, NIC noninflammatory controls; NA not available, T trend for significance
  3. aTotal autologous cells consists of all phenotyped cells with XY probes
  4. bTotal microchimeric cells consists of all cells with XX probes
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Arthritis Research & Therapy

ISSN: 1478-6362

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