Table 5 The summary subchondral bone associations with joint replacement, structural progression and pain in peripheral OA
Subchondral bone feature of OA | Pain and structural associations | ||||||
|---|---|---|---|---|---|---|---|
Knee structure | Knee pain | Hand structure | Hand pain | Hip structure | Hip pain | Ankle structure | |
MRI bone marrow lesions | Progression (i) | LPS (i) | Progression (i) | No LPS (w) | Severity (w) | Severity (n) | Â |
IFP (n) | |||||||
No severity (n) | |||||||
TKR (i) | |||||||
MRI osteophytes | Progression (i) | LPS (n) | Severity (n) | No severity (n) | Â | Â | Â |
TKR (n) | |||||||
MRI bone attrition | No progression (0) | No severity (0) | Severity (n) | No severity (n) | Â | Â | Â |
MRI bone shape or dimensions | Progression (i) | IFP (i) | Â | Â | No severity (0) | Â | Â |
Severity (n) | |||||||
TKR (i) | |||||||
MRI bone cyst | No progression | No LPS (n) | No severity (n) | No severity (n) | Â | Severity (n) | Â |
?severity | |||||||
MRI or CT trabecular morphometry | Progression (n) | Â | Â | Â | Severity (n) | Â | Â |
DXA or CT Peri-articular BMD | Progression (n) | Â | Â | Â | Severity (w) | Â | Â |
2D Bone shape | Severity (w) | Severity (n) | Â | Â | Progression (i) | Â | Â |
THR (i) | |||||||
Scintigraphy | No Progression (0) | Â | Â | No severity (n) | Â | Â | Severity (w) |