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Fig 1 | Arthritis Research & Therapy

Fig 1

From: Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

Fig 1

LD pattern at the IL6R locus. a Identification of the main haplotype blocks. Using Hapmap on 1000 Genomes Project data, we identified two main haplotype blocks covering most of the IL6R sequence. The 5′ block covers an ~38 kb region (154,432,622–154,394,417 bp), and the 3′ block covers an ~6 kb IL6R sequence (154,432,877–154,439,865 bp). Using Haploview software (v 4.2; Broad Institute of MIT/Harvard University, Cambridge, Massachussetts, USA), we searched for tagging SNPs within each haplotype block. b LD pattern associated with SNP rs4845618. LD (r 2, y axis) between SNPs in the IL6R locus and rs4845618 (purple diamond), the SNP most significantly associated with joint damage in RA. LD estimation was obtained from Caucasian European data from Hapmap samples generated by the 1000 Genomes Project [10]. SNPs are colored according to the LD level with rs4845618 (see legend). Markers with high LD (i.e. r 2 >0.8) are mapped within the transcribed region of IL6R

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