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Table 1 Association of IL6R locus SNPs with the severity of joint damage in RA

From: Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

     Discovery phase Replication phase  
SNP Base pair Minor allele MAF βa (95 % CI) P value βa (95 % CI) P value Meta-analysis P valueb
rs4845618 154,400,015 G 0.44 −1.09 (−1.85 to −0.33) 0.0052 −1.01 (−1.74 to −0.28) 0.007 0.00011
rs4453032 154,414,086 G 0.40 0.25 (−0.51 to 1.01) 0.51
rs4845374 154,426,947 A 0.17 1.14 (0.18–2.10) 0.02 0.95 (0.04–1.85) 0.04 0.0021
rs6698040 154,432,948 T 0.21 −0.79 (−1.75 to 0.17) 0.11
rs4379670 154,439,865 T 0.16 −0.64 (−1.72 to 0.44) 0.25
  1. CI confidence interval, IL6R interleukin-6 receptor gene, MAF minor allele frequency, RA rheumatoid arthritis, SNP single nucleotide polymorphism
  2. aCorrelation coefficient estimate, indicating the fold difference in joint damage in the presence of the minor allele (i.e., negative coefficients indicate a decrease in joint damage, positive coefficients indicate an increase of joint damage)
  3. b P value estimated from the meta-analysis of the significance and effect sizes of discovery and replication cohorts
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