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Table 2 Haplotype association results between IL6R locus SNPs with the severity of joint damage in RA

From: Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

  

P valuec

Haplotypea

SNPsb

Discovery phase

Replication phase

TA

rs4845618|rs4845374

0.0099

0.052

GT

rs4845618|rs4845374

0.0037

0.0058

TT

rs4845618|rs4845374

0.38

0.023

GATTT

rs4845618|rs4453032|rs4845374|rs6698040|rs4379670

0.31

–

GATTA

rs4845618|rs4453032|rs4845374|rs6698040|rs4379670

0.14

–

TAACA

rs4845618|rs4453032|rs4845374|rs6698040|rs4379670

0.02

–

TGTCA

rs4845618|rs4453032|rs4845374|rs6698040|rs4379670

0.27

–

GATCA

rs4845618|rs4453032|rs4845374|rs6698040|rs4379670

0.12

–

  1. IL6R interleukin-6 receptor gene, RA rheumatoid arthritis, SNP single nucleotide polymorphism
  2. aImputed haplotype according to the E–M algorithm implemented in PLINK (version 1.07; Center for Human Genetic Research (CHGR), Massachusetts General Hospital (MGH), and the Broad Institute of Harvard and MIT, Boston, Massachusetts)
  3. bList of IL6R tagSNPs used to estimate the haplotypes
  4. cStatistical significance after testing the association of the estimated haplotype with the level of joint damage. Only haplotypes with a frequency >1 % were tested for association
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Arthritis Research & Therapy

ISSN: 1478-6362

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