Fig. 2

Myeloid pten ^-/- animals are protected from collagen-induced arthritis (CIA). a Clinical quantification of paw swelling in wt (n = 7) and myeloid pten ^-/- (n = 13) mice after induction of CIA. Data are expressed as means ± s.e. *P ≤ 0.05, **P ≤ 0.01. b Incidence plot of arthritis of wt and myeloid pten ^-/- after induction of CIA (^* P ≤ 0.05). Plot shows data from one representative experiment of two with similar results. c Quantitative histomorphometric analysis of hind paws of wt and myeloid pten ^-/- mice after induction of CIA. Data are expressed as means ± s.d. *P ≤ 0.05, **P ≤ 0.01. d Representative images and TRAP-stained histologies of hind paws of wt and myeloid pten ^-/- mice. Scale bars, 0.5 mm. e Quantification of anti-collagen IgG antibody levels of wt (n = 7) and myeloid pten ^-/- (n = 13) mice after induction of CIA. Data are means ± s.d. IgG immunoglobulin G, TRAP tartrate-resistant acid phosphatase, wt wild-type