Fig. 2

Expression of methylation enzymes in blood cells of healthy controls (HC) and early rheumatoid arthritis (RA) patients. Normalized relative expression of DNMT1 obtained by quantitative polymerase chain reaction (qPCR) in a T cells, b B cells, and c monocytes, DNMT3A in B cells (d) and of GADD45A in T cells (e) and B cells (f) is shown. Other conventions are as in Fig. 1. All these comparisons were significant. No comparison in other cells subpopulation and none of the DNMT3B analyses were significant