Fig. 2From: Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosisSerum levels of semaphorin 3E (Sema3E) determined by colorimetric sandwich enzyme-linked immunosorbent assay (ELISA). a Serum Sema3E levels in healthy controls, subjects with primary Raynaud's phenomenon (pRP) and patients with systemic sclerosis (SSc). b Serum Sema3E levels in SSc patients according to nailfold videocapillaroscopy (NVC) pattern (early, active and late). c Serum Sema3E levels in SSc patients according to the absence/presence of digital ulcers (DUs). Data are shown as dot plots. Each dot represents a subject. Blue horizontal lines indicate the median value in each group. In each panel, the red dashed line indicates the detection threshold of the ELISA. The nonparametric Mann–Whitney U test for independent samples was used to analyze the serum Sema3E differences between groups. Values of p <0.05 were considered significant; p values are indicated in each panelBack to article page