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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study

Fig. 5

OP3-4 prevented CIA-induced peripheral bone loss at the tibial metaphysis. a, b pQCT was used to measure the bone mineral density (BMD) at the secondary spongiosa of the tibiae. Upper panels, representative scan images from the pQCT analyses; lower panels, trabecular area for each group; right panel, color table for the BMD. c μCT reconstruction images of the tibial metaphysis. Scale bar represents 200 μm. d Trabecular number (Tb.N; measure of the average number of trabeculae per unit length). e Structure model index (SMI; an indicator of the structure of trabeculae). SMI will be 0 for parallel plates and 3 for cylindrical rods. f Trabecular bone pattern factor (TBPf; an indicator of morphological changes of trabecular surface). g Marrow space star volume (V m. space; an indicator of osteoporotic changes). h Trabecular spacing (Tb.Spac). i Degree of connectivity of trabeculae normalized by tissue volume (Conn.D). Data expressed as mean ± SD (n = 6) for each group. **p <0.01 vs. Normal-vehicle; # p <0.05, ## p <0.01 vs. CIA-vehicle. Normal-vehicle group, nonimmunized mice receiving vehicle (20 % DMSO); CIA-vehicle group, immunized mice receiving vehicle (20 % DMSO); CIA-9 mg OP3-4 group, immunized mice receiving 9 mg/kg/day OP3-4 peptide; CIA-18 mg OP3-4 group, immunized mice receiving 18 mg/kg/day OP3-4 peptide. CIA collagen-induced arthritis

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