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Table 1 Demographics and clinical parameters of the MCTD and SSc cohorts

From: Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study

  SSc MCTD
Patients, N 298 162
Females, N (%) 243 (82) 128 (79)
Diffuse cutaneous SSc, N (%) 78 (26) N/A
Age at diagnosis, years, M (SD) 48.3 (15.4) 35.4 (15.7)
Age at blood sampling, M (SD) 56.0 (13.8) 44.7 (14.9)
Disease duration at sampling, years, Mdn (IQR) 4.0 (9) 7.0 (7)
Deceased, N (%) 58 (20) 14 (9)
Observation time, months, M (SD) 55.0 (28.7) 98.8 (27.4)
Classification criteria:   
ACR/EULAR 2013 SSc, N (%) 298 (100) N/A
Alarcon, N (%) N/A 143 (88)
Sharp, N (%) N/A 151 (93)
Kasukawa, N (%) N/A 142 (88)
Pulmonary fibrosis at sampling, N (%) 103/252 (40) 52/148 (35)
% of predicted FVC, N (%) 297 (100) 146 (90)
% of predicted FVC, M (SD) 94,7 (20,5) 92.1 (18.5)
% of predicted DLCO, N (%) 295 (99) 142 (88)
% of predicted DLCO, M (SD) 68.2 (21.7) 73.8 (16.4)
Digital ulcers, N (%) 132/278 (44) 50/155 (32)
Precapillary pulmonary hypertension, N (%) 44 (15) 3 (.05)
Pulmonary arterial hypertension, N (%) 32 (10.7) 2 (.04)
Scleroderma renal crisis, N (%) 12 (4) 0 (0)
  1. MCTD mixed connective tissue disease, SSc systemic sclerosis, N numbers, N/A not applicable, M mean, SD standard deviation, Mdn median, IQR interquartile range, FVC forced vital capacity, DLCO diffusing capacity of the lungs for carbon monoxide