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Table 2 Association between clinical parameters and circulating endostatin in the SSc cohort

From: Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study

Clinical manifestations

Univariable

Multivariablea

Regression coefficient

95 % CI

P value

Regression coefficient

95 % CI

P value

% of predicted FVC

−.14

−.34, −.07

.192

   

% of predicted DLCO

−.33

−.52, −.15

.001

−.18

−.35, −.002

.048

dcSSc vs. lcSSc

10.0

.6, 19.5

.037

   

Pulmonary arterial hypertension

29.3

14.4, 44.2

< .001

15.7

2.2, 29.2

.023

Scleroderma renal crisis

74.6

54.1, 95.0

< .001

77.6

59.3, 100.0

< .001

  1. SSc systemic sclerosis, CI confidence interval, FVC forced vital capacity, DLCO diffusing capacity of the lungs for carbon monoxide, dsSSc diffuse cutaneous SSc, lcSSc limited cutaneous SSc
  2. aVariables in the final multivariable regression model: percentage of predicted DLCO, pulmonary arterial hypertension, scleroderma renal crisis, age and gender