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Table 2 Association between clinical parameters and circulating endostatin in the SSc cohort

From: Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study

Clinical manifestations Univariable Multivariablea
Regression coefficient 95 % CI P value Regression coefficient 95 % CI P value
% of predicted FVC −.14 −.34, −.07 .192    
% of predicted DLCO −.33 −.52, −.15 .001 −.18 −.35, −.002 .048
dcSSc vs. lcSSc 10.0 .6, 19.5 .037    
Pulmonary arterial hypertension 29.3 14.4, 44.2 < .001 15.7 2.2, 29.2 .023
Scleroderma renal crisis 74.6 54.1, 95.0 < .001 77.6 59.3, 100.0 < .001
  1. SSc systemic sclerosis, CI confidence interval, FVC forced vital capacity, DLCO diffusing capacity of the lungs for carbon monoxide, dsSSc diffuse cutaneous SSc, lcSSc limited cutaneous SSc
  2. aVariables in the final multivariable regression model: percentage of predicted DLCO, pulmonary arterial hypertension, scleroderma renal crisis, age and gender