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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production

Fig. 2

IL-22 is required for articular hypernociception and neutrophil migration in AIA. mBSA-immunized wild-type (WT) mice or IL-22−/− mice were challenged i.a. with saline or mBSA (30 μg) and treated with a co-injection of rmIL-22 (0.3 ng) or vehicle. Articular hypernociception (a) and neutrophil migration (b) were evaluated 7 h following the challenge. Data are the means ± SEM (n = 5). *P < 0.05, compared with the saline group; # P < 0.05, compared with the WT mBSA group; and & P < 0.05 compared with the IL-22−/− mBSA group. (−/−) deficient, AIA antigen-induced arthritis, i.a. intra-articular, IL interleukin, mBSA methylated bovine serum albumin, rmIL-22 recombinant murine IL-22

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