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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production

Fig. 3

Lower histopathological score in IL-22-deficient mice than in WT mice with AIA. Histological analysis of knee joints of WT and IL-22−/− immunized mice 7 h after mBSA (30 μg/i.a.) challenge. a Hematoxylin and eosin (H&E)-stained representative histological section (upper panel: magnification, 5×; and lower panel: higher magnification, 20×). b AIA severity was measured by the histological score for synovitis. The histological scoring system used was as follows: none (0), mild (1), moderate (2) or severe (3) synovitis. Data represent the mean ± SEM (n = 6), *P < 0.05, compared with the saline group; # P < 0.05, compared with the WT mBSA group. (−/−) deficient, AIA antigen-induced arthritis, i.a. intra-articular, IL interleukin, mBSA methylated bovine serum albumin, WT wild-type

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