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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production

Fig. 5

Participation of IL-1β in the development of AIA. a The concentrations of IL-1β in the knee joint injected with either 30 μg of mBSA or saline in mBSA-immunized mice were determined at 1, 3, 5 and 7 h after challenge. b Articular hypernociception was evaluated 1–7 h after i.a. injection with either mBSA (30 μg) or saline in mBSA-immunized WT or IL-1R1−/− mice. c Neutrophil recruitment toward the articular cavity 7 h after i.a. administration of mBSA (30 μg) or saline in mBSA-immunized WT or IL-1R1−/− mice. d-f The concentrations of IL-1β (d), KC/CXCL1 (e) and MCP-1/CCL2 (f) in the knee joint injected with mBSA (30 μg) or saline in WT and IL-1R1−/− mBSA-immunized mice were determined at 3 h after challenge. Data are the means ± SEM (n = 5). *P < 0.05, compared with the saline group; and # P < 0.05, compared with the WT mBSA group. (−/−) deficient, AIA antigen-induced arthritis, ELISA enzyme-linked immunosorbent assay, IL interleukin, KC/CXCL1 keratinocyte-derived chemokine, mBSA methylated bovine serum albumin, MCP-1/CCL2 monocyte chemoattractant protein-1, WT wild-type

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