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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production

Fig. 6

IL-1β mediates the pro-inflammatory effects of IL-22 in AIA. a mBSA-immunized mice were injected i.a. with IL-22 (1 ng) or saline and the concentrations of IL-1β were determined at 0.5, 1, 3 and 6 h after challenge. b mBSA-immunized WT or IL-22−/− mice were challenged i.a. with mBSA (30 μg) or saline and treated with a co-injection of IL-22 (0.3 ng) or vehicle. The concentrations of IL-1β were determined 3 h after challenge. c and d mBSA-immunized WT or IL-1R1−/− mice were challenged i.a. with IL-22 (1 ng per joint) or saline and articular hypernociception (c) and neutrophil migration (d) were evaluated 7 h following the challenge. Data are expressed as the means ± SEM (n = 5). *P < 0.05, compared with the saline group; # P < 0.05 compared the WT mBSA or WT IL-22 group; and & P < 0.05 compared with the IL-22−/− mBSA group. (−/−), deficient, AIA antigen-induced arthritis, i.a. intra-articular, IL interleukin, mBSA methylated bovine serum albumin, WT wild-type

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