From: Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells
Pfirrmann grade II
Pfirrmann grade IV
P value
(n = 9)
(n = 23)
Mean age (yr)
13.6 ± 1.5
39.8 ± 11.5
<0.01
Sex (male:female)
2:7
16:7
Diseases
Idiopathic scoliosis: 9
Lumbar disc herniation: 13
Lumbar spinal stenosis: 10