Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Main SS-related features of patients according to the presence or absence of serum HCV-IgG antibodies

From: How hepatitis C virus modifies the immunological profile of Sjögren syndrome: analysis of 783 patients

  Negative HCV-IgG Positive HCV-IgG Bilateral P value
N = 678 N = 105
Mean age, years 56.36 ± 14.83 62.93 ± 11.86 <0.001*
Sex, male 45 (7 %) 17 (16 %) 0.003
Dry mouth 661 (98 %) 103 (98 %) 1
Dry eye 661 (98 %) 104 (99 %) 0.493
Altered ocular tests 559/609 (92 %) 82/88 (93 %) 0.834
Altered parotid scintigraphy 486/554 (88 %) 45/54 (83 %) 0.389
Positive salivary gland biopsy 198/309 (64 %) 21/30 (70 %) 0.556
Criteria SS
 - 1993 only 230 (34 %) 54 (51 %) <0.001
 - 2002 432 (64 %) 38 (26 %)
 - ACR only 16 (2 %) 13 (12 %)
Antinuclear antibody+ 568/676 (84 %) 79/104 (76 %) 0.05
Rheumatoid factor+ 267/663 (40 %) 57/102 (56 %) 0.004
Anti-Ro/SS-A+ 292/676 (43 %) 16/103 (15 %) <0.001*
Anti-La/SS-B+ 200/676 (30 %) 17/103 (17 %) 0.006
Monoclonal gammopathy 85/492 (17 %) 35/75 (47 %) <0.001
Type of monoclonal band
 - mIgA 9 (11 %) 1 (3 %) 0.047
 - mIgG 47 (55 %) 13 (37 %)
 - mIgM 18 (21 %) 15 (43 %)
 - Free chains 11 (13 %) 6 (17 %)
Type of monoclonal light chain
 - Kappa:lambda 50:35 19:16 0.65
Cryoglobulin+ 41/626 (7 %) 63/104 (61 %) <0.001*
Low C3 levels, <0.82 g/l 70/660 (11 %) 37/103 (36 %) <0.001*
Low C4 levels, <0.11 g/l 45/660 (7 %) 49/103 (48 %) <0.001*
Hematological neoplasia 26 (4 %) 9 (9 %) 0.04*
Neoplasia 54 (8 %) 21 (20 %) <0.001*
Death 52 (8 %) 35 (33 %) <0.001
  1. *Statistically significant in the multivariate model.
  2. SS Sjögren syndrome, HCV hepatitis C virus, IgG immunoglobulin G, ACR American College of Rheumatology, SS-A Sjögren syndrome A antigen, SS-B Sjögren syndrome B antigen, mIg circulating monoclonal immunoglobulin, C3 complement component 3, C4 complement component 4Bold numbers: statistically-significant differences in the univariate analysis (p<0.05)