| |
Genotype 1a
|
Genotype 1b
|
Non-1 genotypes
|
Bilateral P value
|
|---|
|
N = 8
|
N = 30
|
N = 5
|
|---|
|
Mean age, years
|
62.62 ± 12.62
|
64.93 ± 9.81
|
46.00 ± 8.15
|
0.002
|
|
Sex, male
|
0 (0 %)
|
8 (27 %)
|
2 (40 %)
|
0.182
|
|
Dry mouth
|
8 (100 %)
|
30 (100 %)
|
5 (100 %)
|
1.000
|
|
Dry eye
|
8 (100 %)
|
30 (100 %)
|
5 (100 %)
|
1.000
|
|
Altered ocular tests
|
5/6 (83 %)
|
23/24 (96 %)
|
4/5 (80 %)
|
0.381
|
|
Altered parotid scintigraphy
|
4/5 (80 %)
|
14/17 (82 %)
|
2/3 (67 %)
|
0.822
|
|
Positive salivary gland biopsy
|
5/5 (100 %)
|
3/5 (60 %)
|
0/2 (0 %)
|
0.037
|
|
Criteria SS
|
|
- 1993 only
|
3 (37 %)
|
20 (67 %)
|
2 (40 %)
|
0.175
|
|
- 2002
|
5 (63 %)
|
7 (23 %)
|
3 (60 %)
|
|
- ACR only
|
0 (0 %)
|
3 (10 %)
|
0 (0 %)
|
|
Antinuclear antibody+
|
6 (75 %)
|
26 (87 %)
|
4 (80 %)
|
0.709
|
|
Rheumatoid factor+
|
3 (37 %)
|
16/29 (55 %)
|
1 (20 %)
|
0.284
|
|
Anti-Ro/SS-A+
|
2 (25 %)
|
3 (10 %)
|
2 (40 %)
|
0.185
|
|
Anti-La/SS-B+
|
1 (12 %)
|
5 (17 %)
|
2 (40 %)
|
0.410
|
|
Monoclonal gammopathy
|
3 (37 %)
|
13/26 (50 %)
|
0/1 (0 %)
|
0.535
|
|
Type of monoclonal band
|
|
- mIgA/mIgG/mIgM/free chains
|
0/0/2/1
|
1/6/5/1
|
0/0/0/0
|
0.34
|
|
- Kappa:lambda light chains
|
1:2
|
6:7
|
0
|
1.000
|
|
Cryoglobulin+
|
4 (50 %)
|
20/29 (69 %)
|
0 (0 %)
|
0.014
|
|
Low C3 levels, <0.82 g/l
|
3 (37 %)
|
12 (40 %)
|
3 (60 %)
|
0.677
|
|
Low C4 levels, <0.11 g/l
|
4 (50 %)
|
13 (43 %)
|
2 (40 %)
|
0.926
|
|
Hematological neoplasia
|
1 (12 %)
|
3 (10 %)
|
1 (20 %)
|
0.809
|
|
Neoplasia
|
1 (12 %)
|
6 (20 %)
|
1 (20 %)
|
0.886
|
|
Death
|
4 (50 %)
|
9 (30 %)
|
0 (0 %)
|
0.161
|
|
Viral load > 5,000,000
|
2 (25 %)
|
11/28 (39 %)
|
0/5 (0 %)
|
0.095
|
|
Max viral load (log)
|
6.36 ± 0.39
|
6.13 ± 0.55
|
5.96 ± 0.38
|
0.350
|
-
SS Sjögren syndrome, HCV hepatitis C virus, IgG immunoglobulin G, ACR American College of Radiology, SS-A Sjögren syndrome A antigen, SS-B Sjögren syndrome B antigen, mIg circulating monoclonal immunoglobulin, C3 complement component 3, C4 complement component 4Bold numbers: statistically-significant differences in the univariate analysis (p<0.05)
