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Table 2 Main SS-related features of patients according to the HCV genotypes (1a, 1b, and non-1 genotypes)
| Genotype 1a | Genotype 1b | Non-1 genotypes | Bilateral P value | |
|---|---|---|---|---|
| N = 8 | N = 30 | N = 5 | ||
| Mean age, years | 62.62 ± 12.62 | 64.93 ± 9.81 | 46.00 ± 8.15 | 0.002 |
| Sex, male | 0 (0 %) | 8 (27 %) | 2 (40 %) | 0.182 |
| Dry mouth | 8 (100 %) | 30 (100 %) | 5 (100 %) | 1.000 |
| Dry eye | 8 (100 %) | 30 (100 %) | 5 (100 %) | 1.000 |
| Altered ocular tests | 5/6 (83 %) | 23/24 (96 %) | 4/5 (80 %) | 0.381 |
| Altered parotid scintigraphy | 4/5 (80 %) | 14/17 (82 %) | 2/3 (67 %) | 0.822 |
| Positive salivary gland biopsy | 5/5 (100 %) | 3/5 (60 %) | 0/2 (0 %) | 0.037 |
| Criteria SS | ||||
| - 1993 only | 3 (37 %) | 20 (67 %) | 2 (40 %) | 0.175 |
| - 2002 | 5 (63 %) | 7 (23 %) | 3 (60 %) | |
| - ACR only | 0 (0 %) | 3 (10 %) | 0 (0 %) | |
| Antinuclear antibody+ | 6 (75 %) | 26 (87 %) | 4 (80 %) | 0.709 |
| Rheumatoid factor+ | 3 (37 %) | 16/29 (55 %) | 1 (20 %) | 0.284 |
| Anti-Ro/SS-A+ | 2 (25 %) | 3 (10 %) | 2 (40 %) | 0.185 |
| Anti-La/SS-B+ | 1 (12 %) | 5 (17 %) | 2 (40 %) | 0.410 |
| Monoclonal gammopathy | 3 (37 %) | 13/26 (50 %) | 0/1 (0 %) | 0.535 |
| Type of monoclonal band | ||||
| - mIgA/mIgG/mIgM/free chains | 0/0/2/1 | 1/6/5/1 | 0/0/0/0 | 0.34 |
| - Kappa:lambda light chains | 1:2 | 6:7 | 0 | 1.000 |
| Cryoglobulin+ | 4 (50 %) | 20/29 (69 %) | 0 (0 %) | 0.014 |
| Low C3 levels, <0.82 g/l | 3 (37 %) | 12 (40 %) | 3 (60 %) | 0.677 |
| Low C4 levels, <0.11 g/l | 4 (50 %) | 13 (43 %) | 2 (40 %) | 0.926 |
| Hematological neoplasia | 1 (12 %) | 3 (10 %) | 1 (20 %) | 0.809 |
| Neoplasia | 1 (12 %) | 6 (20 %) | 1 (20 %) | 0.886 |
| Death | 4 (50 %) | 9 (30 %) | 0 (0 %) | 0.161 |
| Viral load > 5,000,000 | 2 (25 %) | 11/28 (39 %) | 0/5 (0 %) | 0.095 |
| Max viral load (log) | 6.36 ± 0.39 | 6.13 ± 0.55 | 5.96 ± 0.38 | 0.350 |
