Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Main SS-related features of patients according to the HCV genotypes (1a, 1b, and non-1 genotypes)

From: How hepatitis C virus modifies the immunological profile of Sjögren syndrome: analysis of 783 patients

  Genotype 1a Genotype 1b Non-1 genotypes Bilateral P value
N = 8 N = 30 N = 5
Mean age, years 62.62 ± 12.62 64.93 ± 9.81 46.00 ± 8.15 0.002
Sex, male 0 (0 %) 8 (27 %) 2 (40 %) 0.182
Dry mouth 8 (100 %) 30 (100 %) 5 (100 %) 1.000
Dry eye 8 (100 %) 30 (100 %) 5 (100 %) 1.000
Altered ocular tests 5/6 (83 %) 23/24 (96 %) 4/5 (80 %) 0.381
Altered parotid scintigraphy 4/5 (80 %) 14/17 (82 %) 2/3 (67 %) 0.822
Positive salivary gland biopsy 5/5 (100 %) 3/5 (60 %) 0/2 (0 %) 0.037
Criteria SS
 - 1993 only 3 (37 %) 20 (67 %) 2 (40 %) 0.175
 - 2002 5 (63 %) 7 (23 %) 3 (60 %)
 - ACR only 0 (0 %) 3 (10 %) 0 (0 %)
Antinuclear antibody+ 6 (75 %) 26 (87 %) 4 (80 %) 0.709
Rheumatoid factor+ 3 (37 %) 16/29 (55 %) 1 (20 %) 0.284
Anti-Ro/SS-A+ 2 (25 %) 3 (10 %) 2 (40 %) 0.185
Anti-La/SS-B+ 1 (12 %) 5 (17 %) 2 (40 %) 0.410
Monoclonal gammopathy 3 (37 %) 13/26 (50 %) 0/1 (0 %) 0.535
Type of monoclonal band
 - mIgA/mIgG/mIgM/free chains 0/0/2/1 1/6/5/1 0/0/0/0 0.34
 - Kappa:lambda light chains 1:2 6:7 0 1.000
Cryoglobulin+ 4 (50 %) 20/29 (69 %) 0 (0 %) 0.014
Low C3 levels, <0.82 g/l 3 (37 %) 12 (40 %) 3 (60 %) 0.677
Low C4 levels, <0.11 g/l 4 (50 %) 13 (43 %) 2 (40 %) 0.926
Hematological neoplasia 1 (12 %) 3 (10 %) 1 (20 %) 0.809
Neoplasia 1 (12 %) 6 (20 %) 1 (20 %) 0.886
Death 4 (50 %) 9 (30 %) 0 (0 %) 0.161
Viral load > 5,000,000 2 (25 %) 11/28 (39 %) 0/5 (0 %) 0.095
Max viral load (log) 6.36 ± 0.39 6.13 ± 0.55 5.96 ± 0.38 0.350
  1. SS Sjögren syndrome, HCV hepatitis C virus, IgG immunoglobulin G, ACR American College of Radiology, SS-A Sjögren syndrome A antigen, SS-B Sjögren syndrome B antigen, mIg circulating monoclonal immunoglobulin, C3 complement component 3, C4 complement component 4Bold numbers: statistically-significant differences in the univariate analysis (p<0.05)