Table 3 Combination of the main SS-related immunological profiles (ANA/RF, Ro/La, and cryoglobulinemic-related markers) according to the presence or absence of serum HCV-IgG antibodies

ANA/RF combination

Negative HCV-IgG

Positive HCV-IgG

Bilateral P value

N = 306

N = 74

 ANA and RF

94 (31 %)

29 (39 %)

<0.001

 Isolated ANA

200 (65 %)

32 (43 %)

 Isolated RF

12 (4 %)

13 (18 %)

Ro/La combination

Negative HCV-IgG

Positive HCV-IgG

Bilateral P value

N = 314

N = 21

 Anti-Ro and anti-La antibodies

178 (57 %)

12 (57 %)

0.014

 Isolated anti-Ro antibodies

114 (36 %)

4 (19 %)

 Isolated anti-La antibodies

22 (7 %)

5 (24 %)

Cryoglobulinemic-related markers combination

Negative HCV-IgG

Positive HCV-IgG

Bilateral P value

N = 38

N = 60

 Cryoglobulins+RF+low C4

7 (18 %)

28 (47 %)

0.019

 Cryoglobulins+RF

12 (32 %)

13 (22 %)

 Cryoglobulins+low C4

6 (16 %)

10 (17 %)

 Isolated cryoglobulins

13 (34 %)

9 (15 %)