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Table 3 Combination of the main SS-related immunological profiles (ANA/RF, Ro/La, and cryoglobulinemic-related markers) according to the presence or absence of serum HCV-IgG antibodies

From: How hepatitis C virus modifies the immunological profile of Sjögren syndrome: analysis of 783 patients

ANA/RF combination Negative HCV-IgG Positive HCV-IgG Bilateral P value
N = 306 N = 74
 ANA and RF 94 (31 %) 29 (39 %) <0.001
 Isolated ANA 200 (65 %) 32 (43 %)
 Isolated RF 12 (4 %) 13 (18 %)
Ro/La combination Negative HCV-IgG Positive HCV-IgG Bilateral P value
N = 314 N = 21
 Anti-Ro and anti-La antibodies 178 (57 %) 12 (57 %) 0.014
 Isolated anti-Ro antibodies 114 (36 %) 4 (19 %)
 Isolated anti-La antibodies 22 (7 %) 5 (24 %)
Cryoglobulinemic-related markers combination Negative HCV-IgG Positive HCV-IgG Bilateral P value
N = 38 N = 60
 Cryoglobulins+RF+low C4 7 (18 %) 28 (47 %) 0.019
 Cryoglobulins+RF 12 (32 %) 13 (22 %)
 Cryoglobulins+low C4 6 (16 %) 10 (17 %)
 Isolated cryoglobulins 13 (34 %) 9 (15 %)
  1. SS Sjögren syndrome, ANA antinuclear antibodies, RF rheumatoid factor, HCV hepatitis C virus, IgG immunoglobulin G, C4 complement component 4