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Table 4 Main SS-related features of the 17 SS-HCV patients with anti-La antibodies in comparison with the 200 SS patients with anti-La antibodies without HCV infection

From: How hepatitis C virus modifies the immunological profile of Sjögren syndrome: analysis of 783 patients

  Anti-La+ SS patients with HCV infection Anti-La+ SS patients with no HCV infection Bilateral P value
N = 17 N = 200
Mean age, years 59.59 ± 11.87 51.04 ± 15.77 0.03
Sex, male 4 (23 %) 8 (4 %) 0.009*
Dry mouth 16 (94 %) 197 (99 %) 0.280
Dry eye 17 (100 %) 196 (98 %) 1.000
Altered ocular tests 15/16 (94 %) 176/187 (94 %) 1.000
Altered parotid scintigraphy 9/10 (90 %) 151/165 (91 %) 0.602
Positive salivary gland biopsy 3/3 (100 %) 55/61 (90 %) 1.000
Antinuclear antibody+ 14 (82 %) 170/199 (85 %) 0.723
Rheumatoid factor+ 13/17 (77 %) 112/191 (59 %) 0.199
Anti-Ro/SS-A+ 12 (71 %) 178 (89 %) 0.044
Monoclonal gammopathy 7/13 (54 %) 33/166 (20 %) 0.01
Type of monoclonal band
 - mIgA 0 (0 %) 3 (9 %) 0.87
 - mIgG 4 (57 %) 17 (52 %)
 - mIgM 2 (29 %) 9 (27 %)
 - Free chains 1 (14 %) 4 (12 %)
Type of monoclonal light chain
 - Kappa:lambda 2:5 23:10 0.041
Cryoglobulin+ 9 (53 %) 19/188 (10 %) <0.001
Low C3 levels, <0.82 g/l 9 (53 %) 22/196 (11 %) <0.001*
Low C4 levels, <0.11 g/l 11 (65 %) 14/196 (7 %) <0.001*
Hematological neoplasia 0 (0 %) 7 (3.5 %) 1.000
Neoplasia 4 (23.5 %) 17 (8.5 %) 0.067
Death 7 (41 %) 16 (8 %) 0.001
  1. *Statistically significant in the multivariate model
  2. SS Sjögren syndrome, HCV hepatitis C virus, SS-A Sjögren syndrome A antigen, mIg circulating monoclonal immunoglobulin, C3 complement component 3, C4 complement component 4Bold numbers: statistically-significant differences in the univariate analysis (p<0.05)