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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors

Fig. 5

Methotrexate (MTX) inhibits TNF-α release upon lipopolysaccharide (LPS) challenge. Raw 264.7 cells were incubated with increasing concentrations of MTX 24.0 h and 1.5 h before incubation without LPS 1 μM during 4 h. TNF-α levels were then measured as described under “Materials and methods”. Data represent means ± standard error of the mean of four independent experiments

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