Association of CXCL10 and CXCL13 levels with disease activity and cutaneous manifestation in active adult-onset Still’s disease

Table 2 Correlations between C-X-C motif chemokine 10 (CXCL10) and CXCL13 levels and those of disease activity markers in 39 adult-onset Still’s disease patients

Disease activity marker	Correlation coefficient, r (p-value)
Disease activity marker	CXCL10	CXCL13	Systemic score
Systemic score	0.421 (0.008)	0.809 (<0.001)
Leukocytes	0.052 (0.753)	0.21 (0.2)	0.362 (0.024)
Hemoglobin	−0.137 (0.406)	−0.464 (0.003)	−0.3 (0.063)
Platelets	−0.021 (0.899)	0.09 (0.587)	0.042 (0.8)
ESR	−0.132 (0.423)	0.11 (0.504)	0.191 (0.244)
CRP	0.147 (0.373)	0.534 (<0.001)	0.619 (<0.001)
Ferritin	0.444 (0.005)	0.405 (0.011)	0.5 (0.001)
Albumin	−0.216 (0.187)	−0.398 (0.012)	−0.475 (0.002)
Bilirubin	−0.116 (0.482)	−0.369 (0.021)	−0.392 (0.013)
AST	0.412 (0.009)	0.162 (0.325)	0.301 (0.062)
ALT	0.3 (0.064)	0.06 (0.715)	0.209 (0.202)
CXCL10		0.428 (0.007)	0.421 (0.008)
CXCL13	0.428 (0.007)		0.809 (<0.001)

ESR erythrocyte sedimentation rate, CRP C-reactive protein, AST aspartate transaminase, ALT alanine transaminase. Spearman’s correlation coefficients were calculated. The systemic scoring system of Pouchot et al. [28] assigns a score from 0 to 12 with 1 point for each of the following manifestations: fever, typical rash, pleuritis, pneumonia, pericarditis, hepatomegaly or abnormal liver function test data, splenomegaly, lymphadenopathy, leukocytosis ≥ 15,000/mm², sore throat, myalgia, and abdominal pain

ISSN: 1478-6362