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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis

Fig. 2

Specificity for nucleotide binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) stimulation of the method applied. a Toll-like receptor (TLR)4 priming (ultra-pure lipolysaccharide (LPS) (250 pg/mL, 2 h)) followed by ATP pulse (5 mM, 20 min) efficiently activates NLRP3-inflammasome, assessed by IL-1β secretion in supernatants of whole blood cells of healthy controls (n = 15). b No increase in TNFα secreted by peripheral whole blood cells stimulated by the same triggers (n = 12). HC healthy controls, RA rheumatoid arthritis, Casp1Inh caspase1 inhibitor

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