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Table 2 Baseline characteristics of subjects treated with either rituximab or cyclophosphamide and stratified by primary endpoint outcome

From: Reanalysis of the Rituximab in ANCA-Associated Vasculitis trial identifies granulocyte subsets as a novel early marker of successful treatment

 

Rituximab

p Value

Cyclophosphamide

p Value

 

Success, n = 60

Failure, n = 34

 

Success, n = 48

Failure, n = 45

 

Age

53.25

56

0.44

51.3

51.9

0.85

Sex

  

0.52

  

0.68

Male

45 %

53 %

 

50 %

56 %

 

Female

55 %

47 %

 

50 %

44 %

 

ANCA-associated vasculitis type

  

0.66

  

0.27

PR3

67 %

62 %

 

60 %

66 %

 

MPO

33 %

38 %

 

40 %

34 %

 

Newly diagnosed at enrollment

48 %

50 %

1.0

56 %

36 %

0.06

BVAS/WG

7.97 ± 0.36

8.09 ± 0.52

0.85

8.42 ± 0.53

7.60 ± 0.47

0.25

  1. ANCA anti-neutrophil cytoplasmic antibodies, BVAS-WG Birmingham Vasculitis Activity Score for Wegener’s granulomatosis, MPO myeloperoxidase, PR3 proteinase 3