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Table 2 Values for diagnostic utility measures for each of the inflammatory back pain characteristics in relation to the presence of sacroiliitis on MRI, and positive HLA-B27 testing

From: Sponyloarthritis features forecasting the presence of HLA-B27 or sacroiliitis on magnetic resonance imaging in patients with suspected axial spondyloarthritis: results from a cross-sectional study in the ESPeranza Cohort

  Sacroiliitis on MRI HLA-B27
Sen Spe LR+ LR− PPV NPV Sen Spe LR+ LR− PPV NPV
Morning stiffness for >30 minutes 68.5 45.9 1.3 0.7 45.6 68.7 63.3 43.6 1.1 0.8 44.2 62.8
Improvement with exercise, not with rest 31.5 71.4 1.1 0.1 42.3 61.1 33.7 70.2 1.1 0.9 44.4 60.0
Alternating buttock pain 47.7 81.6 2.6 0.6 63.3 70.2 31.9 71.3 1.1 0.9 43.9 59.7
Insidious onset 87.7 27.6 1.2 0.4 44.5 77.1 68.1 37.1 1.1 0.9 43.3 62.3
Awakening in second half of the night 64.6 56.6 1.5 0.6 49.7 70.7 55.2 57.4 1.3 0.8 47.8 64.5
Response to NSAIDs 69.2 43.9 1.2 0.7 45.0 68.3 67.4 43.3 1.2 0.8 45.6 65.4
  1. MRI magnetic resonance imaging, HLA-B27 human leucocyte antigen B27, Sen sensitivity, Spe specificity, LR+ positive likelihood ratio, LR− negative likelihood ratio, PPV positive predictive value, NPV negative predictive value, NSAIDs nonsteroidal anti-inflammatory drugs