Table 3 Values for diagnostic utility measures for each of the inflammatory back pain definitions and other features of SpA in relation to the presence of sacroiliitis on MRI and positive HLA-B27 testing
Sacroiliitis on MRI | HLA-B27 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sen | Spe | LR+ | LR− | PPV | NPV | Sen | Spe | LR+ | LR− | PPV | NPV | |
IBP definition | ||||||||||||
Calin criteria | 51.5 | 70.9 | 1.8 | 0.7 | 54.0 | 68.8 | 36.3 | 74.2 | 1.4 | 0.9 | 49.7 | 62.3 |
Berlin criteria | 72.3 | 50.5 | 1.5 | 0.6 | 49.2 | 73.3 | 64.1 | 49.3 | 1.3 | 0.7 | 47.1 | 66.1 |
ASAS criteria | 47.7 | 77.0 | 2.1 | 0.7 | 57.9 | 68.9 | 31.5 | 80.7 | 1.6 | 0.9 | 53.5 | 62.3 |
IBP definition plus other IBP characteristics | ||||||||||||
Calin + alt. buttock | 30.8 | 94.9 | 6.0 | 0.7 | 80.0 | 67.4 | 17.4 | 86.4 | 1.3 | 1.0 | 51.0 | 56.3 |
Calin + NSAIDs | 36.2 | 80.1 | 1.8 | 0.8 | 54.7 | 65.4 | 28.5 | 75.7 | 1.2 | 0.9 | 48.8 | 56.5 |
Calin + night | 28.0 | 94.9 | 5.5 | 0.8 | 77.8 | 67.4 | 16.2 | 87.9 | 1.3 | 1.0 | 52.3 | 56.3 |
Calin + alt. buttock + night | 26.9 | 94.9 | 5.3 | 0.8 | 77.8 | 66.2 | 16.0 | 88.1 | 1.3 | 1.0 | 52.3 | 56.3 |
Calin + alt. buttock + NSAIDs | 20.0 | 96.9 | 6.5 | 0.8 | 81.3 | 64.6 | 10.4 | 91.0 | 1.2 | 1.0 | 48.4 | 55.5 |
Calin + Night + NSAIDs | 29.2 | 87.2 | 2.3 | 0.8 | 60.3 | 65.0 | 21.5 | 88.3 | 1.8 | 0.9 | 56.3 | 61.5 |
Berlin + Insidious | 64.6 | 62.2 | 1.7 | 0.6 | 53.1 | 72.6 | 50.7 | 53.1 | 1.1 | 0.9 | 46.8 | 57.0 |
Berlin + NSAIDs | 53.8 | 68.4 | 1.7 | 0.7 | 53.0 | 69.1 | 48.9 | 66.1 | 1.4 | 0.8 | 50.4 | 64.7 |
Berlin + insidious + NSAIDs | 47.7 | 76.0 | 2.0 | 0.7 | 56.9 | 68.7 | 34.0 | 67.2 | 1.0 | 1.0 | 45.8 | 55.6 |
ASAS + alt. Buttock | 30.8 | 94.4 | 5.5 | 0.7 | 78.4 | 94.4 | 18.1 | 86.4 | 1.3 | 0.9 | 52.0 | 56.5 |
ASAS + NSAIDs | 36.9 | 86.2 | 2.7 | 0.7 | 64.0 | 67.3 | 24.4 | 82.0 | 1.4 | 0.9 | 56.4 | 61.9 |
ASAS + stiffness | 39.2 | 81.1 | 2.1 | 0.7 | 58.0 | 66.8 | 31.3 | 76.3 | 1.3 | 0.9 | 51.7 | 57.7 |
ASAS + alt. Buttock + NSAIDs | 21.5 | 96.4 | 6.0 | 0.8 | 80.0 | 64.9 | 10.7 | 94.3 | 1.9 | 0.9 | 56.9 | 94.3 |
ASAS + stiffness + NSAIDs | 28.5 | 88.8 | 2.5 | 0.8 | 62.7 | 65.2 | 19.4 | 83.1 | 1.1 | 1.0 | 48.3 | 55.9 |
ASAS + stiffness + alt. buttock | 26.9 | 94.9 | 5.3 | 0.8 | 77.8 | 66.2 | 16.0 | 88.1 | 1.3 | 1.0 | 52.3 | 56.3 |
Other SpA features | ||||||||||||
Enthesitis | 11.5 | 84.7 | 0.8 | 1.0 | 33.3 | 59.1 | 17.8 | 85.1 | 1.2 | 0.9 | 85.1 | 45.7 |
Peripheral arthritis | 13.8 | 90.3 | 1.4 | 0.9 | 48.6 | 61.2 | 16.7 | 87.7 | 1.4 | 0.9 | 87.7 | 48.9 |
Dactylitis | 23.1 | 94.4 | 4.1 | 0.8 | 21.4 | 59.3 | 4.8 | 96.9 | 1.6 | 09 | 96.9 | 52.0 |
Uveitis | 6.2 | 95.9 | 1.5 | 0.9 | 50.0 | 60.6 | 8.1 | 96.9 | 2.6 | 0.9 | 96.9 | 64.7 |
Psoriasis | 10.0 | 88.8 | 0.9 | 1.0 | 37.1 | 59.8 | 7.0 | 83.8 | 0.4 | 1.1 | 83.8 | 23.5 |
Inflammatory bowel disease | 23.1 | 96.4 | 6.4 | 0.8 | 30.0 | 59.8 | 1.5 | 94.5 | 0.3 | 1.0 | 94.5 | 16.0 |
Family history of SpA | 27.7 | 73.0 | 1.0 | 0.9 | 40.4 | 60.3 | 33.7 | 80.2 | 1.7 | 0.8 | 80.2 | 54.5 |
Elevated CRP | 40.8 | 77.5 | 1.8 | 0.8 | 55.1 | 66.0 | 38.5 | 77.1 | 1.7 | 0.8 | 77.1 | 54.6 |
HLA-B27 | 59.7 | 65.1 | 1.7 | 0.6 | 53.5 | 70.6 | – | – | – | – | – | – |