| Shared epitope |  |  |  |
 | No, n (%) | Yes, n (%) | OR (95 % CI) | P value |
CCP-2− | 140 (57) | 107 (43) | Reference |  |
CCP-2+ | 54 (21) | 199 (79) | 4.82 (3.26-7.14) | <0.001 |
CCP-2−Multiplex− | 93 (55) | 78 (46) | Reference |  |
CCP-2−Multiplex+ | 47 (60) | 29 (39) | 0.74 (0.42-1.28) | 0.28 |
CCP-2−Multiplex+ | 47 (62) | 29 (38) | Reference |  |
CCP-2+Multiplex+ | 51 (21) | 192 (79) | 6.10 (3.50-10.64) | <0.001 |
 | Ever smoker |  |  |  |
 | No, n (%) | Yes, n (%) | OR (95 % CI) | P value |
CCP-2− | 274 (78) | 78 (22) | Reference |  |
CCP-2+ | 301 (69) | 138 (31) | 1.61 (1.17-2.22) | 0.004 |
CCP-2−Multiplex− | 183 (79) | 54 (21) | Reference |  |
CCP-2−Multiplex+ | 90 (79) | 24 (21) | 0.90 (0.53-1.56) | 0.71 |
CCP-2−Multiplex+ | 90 (79) | 24 (21) | Reference |  |
CCP-2+Multiplex+ | 281 (71) | 125 (29) | 1.67 (1.01-2.74) | 0.004 |